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Recombinant Mouse Pitrm1 Protein, Myc/DDK-tagged

Cat.No. : Pitrm1-4883M
Product Overview : Purified recombinant protein of mouse full-length pitrilysin metallepetidase 1 (Pitrm1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
  • Specification
  • Gene Information
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Description : Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 117.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Pitrm1 pitrilysin metallepetidase 1 [ Mus musculus (house mouse) ]
Official Symbol : Pitrm1
Synonyms : PITRM1; pitrilysin metallepetidase 1; presequence protease, mitochondrial; pitrilysin metalloprotease 1; pitrilysin metalloproteinase 1; nuclear transplantation upregulated protein 1; MP1; MP-1; PreP; Ntup1; AA410010; mKIAA1104; 2310012C15Rik
Gene ID : 69617
mRNA Refseq : NM_145131
Protein Refseq : NP_660113
UniProt ID : Q8K411

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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