Recombinant Mouse Pla2g1b protein(Met1-Cys146), His-tagged

• Cat.No.: Pla2g1b-1185M
• Product Overview: Recombinant Mouse PLA2G1B (NP_035237.1) extracellular domain (Met 1-Cys 146) was expressed in HEK293, fused with a polyhistidine tag at the C-terminus.

Specification

• Source: HEK293
• Species: Mouse
• Tag: C-His
• Protein length: Met1-Cys146
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The secreted recombinant mouse PLA2G1B consists of 142 amino acids and has a predicted molecular mass of 16.3 kDa. rmPLA2G1B migrates as an approximately 18 kDa band in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: > 96 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
• Publication:
  Epithelial-Cell-Derived Phospholipase A 2 Group 1B Is an Endogenous Anthelmintic. (2017)

Gene Information

• Gene Name: Pla2g1b phospholipase A2, group IB, pancreas [ Mus musculus ]
• Official Symbol: Pla2g1b
• Synonyms: PLA2G1B; phospholipase A2, group IB, pancreas; phospholipase A2; PLA2-Ib; group IB phospholipase A2; phosphatidylcholine 2-acylhydrolase 1B; Pla2a; sPLA2IB; MGC6679
• Gene ID: 18778
• mRNA Refseq: NM_011107
• Protein Refseq: NP_035237

Reviews

03/12/2020

Its exceptional purity and stability make it an ideal choice for a wide range of applications, ensuring reliable and reproducible results.

10/16/2017

The PLA2G1B protein comes highly recommended for its exceptional performance in various research applications.

01/09/2016

Its unique characteristics contribute to obtaining clear and detailed structural information, allowing researchers to gain insights into protein interactions and conformational changes.

Q&As

How is PLA2G1B involved in cardiovascular diseases?

PLA2G1B is associated with atherosclerosis and other cardiovascular conditions due to its involvement in lipid metabolism and inflammation.

Are there potential neuroprotective effects of modulating PLA2G1B activity?

Modulating PLA2G1B activity could be explored for potential neuroprotective effects, given its involvement in processes related to neuroinflammation.

In what diseases is PLA2G1B dysregulation observed?

Dysregulation of PLA2G1B has been linked to inflammatory disorders, cardiovascular diseases, and certain cancers.

Can PLA2G1B be a therapeutic target for inflammatory conditions?

Yes, targeting PLA2G1B may be a potential therapeutic strategy for inflammatory diseases, as it plays a role in the production of inflammatory mediators.

Can PLA2G1B inhibitors be used for treating cancer?

Inhibiting PLA2G1B may be explored as a therapeutic approach in cancer treatment by disrupting lipid metabolism and inhibiting cancer cell proliferation.