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Recombinant Mouse Ppp1r9b Protein, Myc/DDK-tagged

Cat.No. : Ppp1r9b-5076M
Product Overview : Purified recombinant protein of mouse full-length protein phosphatase 1, regulatory subunit 9B (Ppp1r9b), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
  • Specification
  • Gene Information
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Description : Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1. Required for hepatocyte growth factor (HGF)-induced cell migration.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 90 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Ppp1r9b protein phosphatase 1, regulatory subunit 9B [ Mus musculus (house mouse) ]
Official Symbol : Ppp1r9b
Synonyms : Ppp1r9b; protein phosphatase 1, regulatory subunit 9B; s; SPL; Spn; neurabin-2; neurabin-II; spinophilin
Gene ID : 217124
mRNA Refseq : NM_172261
Protein Refseq : NP_758465
UniProt ID : Q6R891

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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