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Recombinant Mouse Prkra Protein, Myc/DDK-tagged

Cat.No. : Prkra-5127M
Product Overview : Purified recombinant protein of mouse full-length protein kinase, interferon inducible double stranded RNA dependent activator (Prkra), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 34.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Prkra protein kinase, interferon inducible double stranded RNA dependent activator [ Mus musculus (house mouse) ]
Official Symbol : Prkra
Synonyms : PRKRA; protein kinase, interferon inducible double stranded RNA dependent activator; interferon-inducible double stranded RNA-dependent protein kinase activator A; PKR-associated protein X; PKR-associating protein X; protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double stranded RNA-dependent activator; PRK; RAX; Pact; lear; AV120107
Gene ID : 23992
mRNA Refseq : NM_011871
Protein Refseq : NP_036001
UniProt ID : Q9WTX2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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