Recombinant Mouse Psme4 Protein, MYC/DDK-tagged


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Recombinant Mouse Psme4 Protein, MYC/DDK-tagged

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Cat.No. : Psme4-229M
Product Overview : Purified recombinant protein of full-length mouse proteasome (prosome, macropain) activator subunit 4 (Psme4), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
Source : HEK293T
Species : Mouse
Molecular Mass : 211.6 kDa
Purity : >80%, as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Psme4 proteasome (prosome, macropain) activator subunit 4 [ Mus musculus (house mouse) ]
Official Symbol : Psme4
Synonyms : Psme4; proteasome (prosome, macropain) activator subunit 4; TEMO; AA409398; AU041366; mKIAA0077; proteasome activator complex subunit 4; proteasome activator PA200
Gene ID : 103554
mRNA Refseq : NM_134013
Protein Refseq : NP_598774
UniProt ID : Q5SSW2
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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