|Product Overview:||Recombinant Mouse Qsox1(Ser36-Ala550) fused with an N-terminal Met and 6-His tag was expressed in E. coli.|
|Description:||Sulfhydryl Oxidase-1 (QSOX1) is an enzyme that contains thioredoxin and sulfhydryl oxidase domains. It is synthesized with a C-terminal transmembrane segment, but soluble secreted forms can be generated by alternative splicing or proteolytic shedding within the Golgi. Within the region encompassing both enzymatic domains and the central region, mouse QSOX1 shares 79% and 92% aa sequence identity with human and rat QSOX1, respectively. It plays a role in nascent protein folding by mediating disulfide oxidation. This activity is required for Laminin incorporation into the extracellular matrix. QSOX1 is up-regulated in many cancers and supports tumor cell proliferation and invasion.|
|Predicted N Terminal:||Met|
|Form:||Supplied as a 0.2 μm filtered solution in Tris and NaCl.|
|Bio-activity:||Measured by its ability to produce hydrogen peroxide during the oxidation of Dithiothreitol (DTT). The specific activity is >1,200 pmol/min/μg.|
|Molecular Mass:||Predicted Molecular Mass: 59 kDa
SDS-PAGE: 56 kDa, reducing conditions
|Endotoxin:||<0.1 EU per 1 μg of the protein by the LAL method.|
|Purity:||>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.|
|Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
6 months from date of receipt, -20 to -70 centigrade as supplied.
3 months, -20 to -70 centigrade under sterile conditions after opening.
|Gene Name:||Qsox1 quiescin Q6 sulfhydryl oxidase 1 [ Mus musculus ]|
|Synonyms:||QSOX1; quiescin Q6 sulfhydryl oxidase 1; sulfhydryl oxidase 1; mSOx; skin sulfhydryl oxidase; SOx; QSOX; Qscn6; 1300003H02Rik;|
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