Active Recombinant Mouse Qsox1 protein, His-tagged

• Cat.No.: Qsox1-266M
• Product Overview: Recombinant Mouse Qsox1(Ser36-Ala550) fused with an N-terminal Met and 6-His tag was expressed in E. coli.

Specification

• Description: Sulfhydryl Oxidase-1 (QSOX1) is an enzyme that contains thioredoxin and sulfhydryl oxidase domains. It is synthesized with a C-terminal transmembrane segment, but soluble secreted forms can be generated by alternative splicing or proteolytic shedding within the Golgi. Within the region encompassing both enzymatic domains and the central region, mouse QSOX1 shares 79% and 92% aa sequence identity with human and rat QSOX1, respectively. It plays a role in nascent protein folding by mediating disulfide oxidation. This activity is required for Laminin incorporation into the extracellular matrix. QSOX1 is up-regulated in many cancers and supports tumor cell proliferation and invasion.
• Source: E. coli
• Species: Mouse
• Tag: His
• Predicted N Terminal: Met
• Form: Supplied as a 0.2 μm filtered solution in Tris and NaCl.
• Bio-activity: Measured by its ability to produce hydrogen peroxide during the oxidation of Dithiothreitol (DTT). The specific activity is >1,200 pmol/min/μg.
• Molecular Mass: Predicted Molecular Mass: 59 kDa
  SDS-PAGE: 56 kDa, reducing conditions
• Endotoxin: <0.1 EU per 1 μg of the protein by the LAL method.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  6 months from date of receipt, -20 to -70 centigrade as supplied.
  3 months, -20 to -70 centigrade under sterile conditions after opening.

Gene Information

• Gene Name: Qsox1 quiescin Q6 sulfhydryl oxidase 1 [ Mus musculus ]
• Official Symbol: Qsox1
• Synonyms: QSOX1; quiescin Q6 sulfhydryl oxidase 1; sulfhydryl oxidase 1; mSOx; skin sulfhydryl oxidase; SOx; QSOX; Qscn6; 1300003H02Rik
• Gene ID: 104009
• mRNA Refseq: NM_001024945
• Protein Refseq: NP_001020116
• UniProt ID: Q8BND5

Reviews

11/15/2022

QSOX1 has good heat resistance and remains active when treated at high temperatures for a long time.

07/29/2022

The safety is very high, so you can use it with confidence.

01/26/2022

There are no complicated experimental procedures, making it suitable for novices.

Q&As

What is the treatment for QSOX1?

There is currently no specific treatment for QSOX1. However, drugs that target their associated signal transduction pathways or binding targets may have potential therapeutic value.

Is QSOX1 associated with cardiovascular disease?

Recent studies have shown that QSOX1 may be associated with the occurrence and progression of cardiovascular disease. In atherosclerotic lesions, the expression level of QSOX1 may change, affecting the development of the lesion.

Is QSOX1 associated with other diseases?

Recent studies have shown that QSOX1 may be involved in the development and progression of certain cancers. In addition, QSOX1 may also be associated with neurodegenerative diseases.

How to measure the expression level of QSOX1?

QSOX1 expression levels can be detected by gene sequencing, immunohistochemistry, and western blotting.

Can QSOX1 be used as a biomarker for cardiovascular disease?

At present, there is insufficient research on whether QSOX1 can be used as a biomarker for cardiovascular disease, and further verification is needed.

How about the interactions between QSOX1 and other molecules or drugs?

There are multiple interactions between QSOX1 and other molecules and drugs. For example, QSOX1 can bind to specific cytokines, which affect the growth and differentiation of cells. In addition, some drugs can also affect QSOX1 expression levels or function.