Recombinant Mouse Rasgrp2 Protein, Myc/DDK-tagged

• Cat.No.: Rasgrp2-5390M
• Product Overview: Purified recombinant protein of mouse full-length RAS, guanyl releasing protein 2 (Rasgrp2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 69.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rasgrp2 RAS, guanyl releasing protein 2 [ Mus musculus (house mouse) ]
• Official Symbol: Rasgrp2
• Synonyms: RASGRP2; RAS, guanyl releasing protein 2; RAS guanyl-releasing protein 2; CalDAG-GEFI; F25B3.3 kinase like protein; F25B3.3 kinase-like protein; RAP 1A protein-specific guanine nucleotide exchange factor 1; calcium and DAG-regulated guanine nucleotide exchange factor I; CDC25L; Caldaggef1
• Gene ID: 19395
• mRNA Refseq: NM_011242
• Protein Refseq: NP_035372
• UniProt ID: Q9QUG9