Recombinant Mouse Rnaset2a Protein, MYC/DDK-tagged

• Cat.No.: Rnaset2a-007M
• Product Overview: Purified recombinant protein of full-length mouse ribonuclease T2A (Rnaset2a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs.
• Molecular Mass: 30.1 kDa
• Purity: >80%, as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rnaset2a ribonuclease T2A [ Mus musculus (house mouse) ]
• Official Symbol: Rnaset2a
• Synonyms: Rnaset2a; ribonuclease T2A; C79750; Rnaset2; RNASE6PL; 0610007O07Rik; 4833423A10Rik; 4930532K22Rik; ribonuclease T2-A; ribonuclease 6; ribonuclease 6-A; ribonuclease T2; EC 4.6.1.19
• Gene ID: 100037283
• mRNA Refseq: NM_001083938
• Protein Refseq: NP_001077407
• UniProt ID: Q5FWA0