Recombinant Mouse Rnaset2a Protein, MYC/DDK-tagged Rnaset2a-007M

Recombinant Mouse Rnaset2a Protein, MYC/DDK-tagged


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Recombinant Mouse Rnaset2a Protein, MYC/DDK-tagged

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Cat.No. : Rnaset2a-007M
Product Overview : Purified recombinant protein of full-length mouse ribonuclease T2A (Rnaset2a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs.
Source : HEK293T
Species : Mouse
Molecular Mass : 30.1 kDa
Purity : >80%, as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Rnaset2a ribonuclease T2A [ Mus musculus (house mouse) ]
Official Symbol : Rnaset2a
Synonyms : Rnaset2a; ribonuclease T2A; C79750; Rnaset2; RNASE6PL; 0610007O07Rik; 4833423A10Rik; 4930532K22Rik; ribonuclease T2-A; ribonuclease 6; ribonuclease 6-A; ribonuclease T2; EC
Gene ID : 100037283
mRNA Refseq : NM_001083938
Protein Refseq : NP_001077407
UniProt ID : Q5FWA0

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