- Mouse(1)
Recombinant Mouse Rnaset2a Protein, MYC/DDK-tagged
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| Cat.No. : | Rnaset2a-007M |
| Product Overview : | Purified recombinant protein of full-length mouse ribonuclease T2A (Rnaset2a), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
| Description : | Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs. |
| Source : | HEK293T |
| Species : | Mouse |
| Tag : | MYC/DDK |
| Molecular Mass : | 30.1 kDa |
| Purity : | >80%, as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : | Store at -80 centigrade after receiving vials. |
| Concentration : | >50 ug/mL as determined by microplate BCA method |
| Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Gene Name : | Rnaset2a ribonuclease T2A [ Mus musculus (house mouse) ] |
| Official Symbol : | Rnaset2a |
| Synonyms : | Rnaset2a; ribonuclease T2A; C79750; Rnaset2; RNASE6PL; 0610007O07Rik; 4833423A10Rik; 4930532K22Rik; ribonuclease T2-A; ribonuclease 6; ribonuclease 6-A; ribonuclease T2; EC 4.6.1.19 |
| Gene ID : | 100037283 |
| mRNA Refseq : | NM_001083938 |
| Protein Refseq : | NP_001077407 |
| UniProt ID : | Q5FWA0 |
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