Recombinant Mouse Rrm2b Protein, Myc/DDK-tagged

• Cat.No.: Rrm2b-5628M
• Product Overview: Purified recombinant protein of mouse full-length ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 40.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rrm2b ribonucleotide reductase M2 B (TP53 inducible) [ Mus musculus (house mouse) ]
• Official Symbol: Rrm2b
• Synonyms: RRM2B; ribonucleotide reductase M2 B (TP53 inducible); ribonucleoside-diphosphate reductase subunit M2 B; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2
• Gene ID: 382985
• mRNA Refseq: NM_199476
• Protein Refseq: NP_955770
• UniProt ID: Q6PEE3