Recombinant Mouse Rtn4rl2 Protein, Myc/DDK-tagged

• Cat.No.: Rtn4rl2-5645M
• Product Overview: Purified recombinant protein of mouse full-length reticulon 4 receptor-like 2 (Rtn4rl2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG. Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton.
• Molecular Mass: 46.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rtn4rl2 reticulon 4 receptor-like 2 [ Mus musculus (house mouse) ]
• Official Symbol: Rtn4rl2
• Synonyms: Rtn4rl2; reticulon 4 receptor-like 2; Ng; Ngr; Ngr2; Ngrh1; Ngrl3; reticulon-4 receptor-like 2; nogo receptor-like 3; nogo-66 receptor homolog 1; nogo-66 receptor-related protein 2
• Gene ID: 269295
• mRNA Refseq: NM_199223
• Protein Refseq: NP_954693
• UniProt ID: Q7M6Z0