Recombinant Mouse Sav1 Protein, Myc/DDK-tagged
Cat.No. : | Sav1-5697M |
Product Overview : | Purified recombinant protein of mouse full-length salvador family WW domain containing 1 (Sav1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 44.9 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Sav1 salvador family WW domain containing 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Sav1 |
Synonyms : | SAV1; salvador homolog 1 (Drosophila); protein salvador homolog 1; 45 kDa WW domain protein; WW domain-containing protein 3; WW domain-containing protein 4; Sav; Salv; WW45; Wwp3; Wwp4; 1700040G09Rik |
Gene ID : | 64010 |
mRNA Refseq : | NM_022028 |
Protein Refseq : | NP_071311 |
UniProt ID : | Q8VEB2 |
Products Types
◆ Recombinant Protein | ||
SAV1-7910M | Recombinant Mouse SAV1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SAV1-4892R | Recombinant Rat SAV1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SAV1-3899R | Recombinant Rhesus Macaque SAV1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SAV1-1283Z | Recombinant Zebrafish SAV1 | +Inquiry |
SAV1-4082R | Recombinant Rhesus monkey SAV1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
SAV1-2053HCL | Recombinant Human SAV1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket