Recombinant Mouse Sh3bp4 Protein, Myc/DDK-tagged

• Cat.No.: Sh3bp4-5842M
• Product Overview: Purified recombinant protein of mouse full-length SH3-domain binding protein 4 (Sh3bp4), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 108 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Sh3bp4 SH3-domain binding protein 4 [ Mus musculus (house mouse) ]
• Official Symbol: Sh3bp4
• Synonyms: SH3BP4; SH3-domain binding protein 4; SH3 domain-binding protein 4; BOG25; AI594717; AW227605
• Gene ID: 98402
• mRNA Refseq: NM_133816
• Protein Refseq: NP_598577
• UniProt ID: Q921I6