Recombinant Mouse Sh3bp5 Protein, Myc/DDK-tagged

• Cat.No.: Sh3bp5-5843M
• Product Overview: Purified recombinant protein of mouse full-length SH3-domain binding protein 5 (BTK-associated) (Sh3bp5), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 51.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Sh3bp5 SH3-domain binding protein 5 (BTK-associated) [ Mus musculus (house mouse) ]
• Official Symbol: Sh3bp5
• Synonyms: SH3BP5; SH3-domain binding protein 5 (BTK-associated); SH3 domain-binding protein 5; SH3 domain-binding protein that preferentially associates with BTK; Sab; SH3BP-5; AI606498
• Gene ID: 24056
• mRNA Refseq: NM_011894
• Protein Refseq: NP_036024
• UniProt ID: Q9Z131