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Recombinant Mouse Snx27 Protein, Myc/DDK-tagged

Cat.No. : Snx27-6029M
Product Overview : Purified recombinant protein of mouse full-length sorting nexin family member 27 (Snx27), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 61 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Snx27 sorting nexin family member 27 [ Mus musculus (house mouse) ]
Official Symbol : Snx27
Synonyms : SNX27; sorting nexin family member 27; sorting nexin-27; ESTM45; ESTM47; R75405; mKIAA0488; 5730552M22Rik
Gene ID : 76742
mRNA Refseq : NM_001082484
Protein Refseq : NP_001075953
UniProt ID : Q3UHD6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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