Recombinant Mouse Tollip Protein, Myc/DDK-tagged

• Cat.No.: Tollip-6578M
• Product Overview: Purified recombinant protein of mouse full-length toll interacting protein (Tollip), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates.
• Molecular Mass: 30.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tollip toll interacting protein [ Mus musculus (house mouse) ]
• Official Symbol: Tollip
• Synonyms: TOLLIP; toll interacting protein; toll-interacting protein; 4930403G24Rik; 4931428G15Rik
• Gene ID: 54473
• mRNA Refseq: NM_023764
• Protein Refseq: NP_076253
• UniProt ID: Q9QZ06