Recombinant Mouse Traf3 Protein, Myc/DDK-tagged

• Cat.No.: Traf3-6618M
• Product Overview: Purified recombinant protein of mouse full-length TNF receptor-associated factor 3 (Traf3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 64.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Traf3 TNF receptor-associated factor 3 [ Mus musculus (house mouse) ]
• Official Symbol: Traf3
• Synonyms: TRAF3; TNF receptor-associated factor 3; TRAFAMN; CD40 receptor-associated factor 1; amn; LAP1; CAP-1; CRAF1; T-BAM; CD40bp; AI528849
• Gene ID: 22031
• mRNA Refseq: NM_011632
• Protein Refseq: NP_035762
• UniProt ID: Q60803