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Recombinant Mouse Trim25 Protein, Myc/DDK-tagged

Cat.No. : Trim25-6647M
Product Overview : Purified recombinant protein of mouse full-length tripartite motif protein 25 (cDNA clone MGC:6886 IMAGE:2651664), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection. Mediates 'Lys-63'-linked polyubiquitination of IFIH1. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 70.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Trim25 tripartite motif-containing 25 [ Mus musculus (house mouse) ]
Official Symbol : Trim25
Synonyms : Trim25; tripartite motif-containing 25; EFP; Zfp14; Zfp147; AA960166; AL022677; E3 ubiquitin/ISG15 ligase TRIM25; RING-type E3 ubiquitin transferase TRIM25; estrogen-responsive finger protein; tripartite motif protein 25; tripartite motif-containing protein 25; ubiquitin/ISG15-conjugating enzyme TRIM25; zinc finger protein 147; EC 2.3.2.27; EC 6.3.2.n3
Gene ID : 217069
mRNA Refseq : NM_009546
Protein Refseq : NP_033572
UniProt ID : Q61510

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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