Recombinant Mouse Trim39 Protein, Myc/DDK-tagged

• Cat.No.: Trim39-6655M
• Product Overview: Purified recombinant protein of mouse full-length tripartite motif protein 39 (cDNA clone MGC:19239 IMAGE:3666785), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation.
• Molecular Mass: 57.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Trim39 tripartite motif-containing 39 [ Mus musculus (house mouse) ]
• Official Symbol: Trim39
• Synonyms: Trim39; tripartite motif-containing 39; tf; Rnf; tfp; Rnf23; RBCC-B30.; mKIAA4179; RBCC-B30.2; 1100001D15Rik; E130103K13Rik; E3 ubiquitin-protein ligase TRIM39; RING-B box-coiled-coil-B30.2; RING-type E3 ubiquitin transferase TRIM39; ring finger protein 23; testis-abundant finger protein; tripartite motif-containing protein 39; EC 2.3.2.27
• Gene ID: 79263
• mRNA Refseq: NM_024468
• Protein Refseq: NP_077788
• UniProt ID: Q9ESN2