Recombinant Mouse TXNIP Protein (1-397 aa), His-tagged

• Cat.No.: TXNIP-1689M
• Product Overview: Recombinant Mouse TXNIP Protein (1-397 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Full Length.

Specification

• Description: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) . Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.
• Source: Yeast
• Species: Mouse
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 46.4 kDa
• Protein length: 1-397 aa
• AA Sequence: MVMFKKIKSFEVVFNDPEKVYGSGE KVAGRVIVEVCEVTRVKAVRILACG VAKVLWMQGSQQCKQTLDYLRYEDT LLLEEQPTAGENEMVIMRPGNKYEY KFGFELPQGPLGTSFKGKYGCVDYW VKAFLDRPSQPTQEAKKNFEVMDLV DVNTPDLMAPVSAKKEKKVSCMFIP DGRVSVSARIDRKGFCEGDDISIHA DFENTCSRIVVPKAAIVARHTYLAN GQTKVFTQKLSSVRGNHIISGTCAS WRGKSLRVQKIRPSILGCNILKVEY SLLIYVSVPGSKKVILDLPLVIGSR SGLSSRTSSMASRTSSEMSWIDLNI PDTPEAPPCYMDIIPEDHRLESPTT PLLDDVDDSQDSPIFMYAPEFQFMP PPTYTEVDPCVLNNNNNNNNVQ
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: Txnip thioredoxin interacting protein [ Mus musculus ]
• Official Symbol: TXNIP
• Synonyms: TXNIP; THIF; Tbp-2; VDUP1; Hyplip1; AA682105; 1200008J08Rik
• Gene ID: 56338
• mRNA Refseq: NM_001009935
• Protein Refseq: NP_001009935
• UniProt ID: Q8BG60