Recombinant Mouse Usp3 Protein, Myc/DDK-tagged

• Cat.No.: Usp3-6874M
• Product Overview: Purified recombinant protein of mouse full-length ubiquitin specific peptidase 3 (Usp3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: The protein encoded by this gene is a chromatin-associated histone 2A and 2B deubiquitinating enzyme that negatively regulates the DNA damage response. Mice deficient for this enzyme have reduced hematopoietic stem cell reserves, demonstrating a requirement in hematopoietic stem cell homeostasis. In addition, knock down of protein levels results in spontaneous tumor development and shortened lifespan, consistent with a function in preserving chromosomal integrity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 58.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Usp3 ubiquitin specific peptidase 3 [ Mus musculus (house mouse) ]
• Official Symbol: Usp3
• Synonyms: USP3; ubiquitin specific peptidase 3; ubiquitin carboxyl-terminal hydrolase 3; ubiquitin thioesterase 3; deubiquitinating enzyme 3; ubiquitin thiolesterase 3; ubiquitin specific protease 3; ubiquitin-specific-processing protease 3; AA409661; BC017156; MGC28886
• Gene ID: 235441
• mRNA Refseq: NM_144937
• Protein Refseq: NP_659186
• UniProt ID: Q91W36