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Recombinant Mouse Usp44 Protein, Myc/DDK-tagged

Cat.No. : Usp44-6880M
Product Overview : Purified recombinant protein of mouse full-length ubiquitin specific peptidase 44 (Usp44), transcript variant 2, with C-terminal MYC/DDK tag, expressed in HEK293T cells.
  • Specification
  • Gene Information
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Description : Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 58 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Usp44 ubiquitin specific peptidase 44 [ Mus musculus (house mouse) ]
Official Symbol : Usp44
Synonyms : Usp44; ubiquitin specific peptidase 44; E430004F17Rik; ubiquitin carboxyl-terminal hydrolase 44; deubiquitinating enzyme 44; inactive deubiquitinating enzyme 44; inactive ubiquitin carboxyl-terminal hydrolase 44; inactive ubiquitin thioesterase 44; inactive ubiquitin-specific-processing protease 44; ubiquitin specific peptidase 49 pseudogene; ubiquitin thioesterase 44; EC 3.4.19.12
Gene ID : 327799
mRNA Refseq : NM_183199
UniProt ID : Q8C2S0

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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