Recombinant Mouse Vps36 Protein, Myc/DDK-tagged

• Cat.No.: Vps36-6939M
• Product Overview: Purified recombinant protein of Mouse vacuolar protein sorting 36 (Vps36), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 43.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Vps36 vacuolar protein sorting 36 [ Mus musculus (house mouse) ]
• Official Symbol: Vps36
• Synonyms: VPS36; vacuolar protein sorting 36 (yeast); vacuolar protein-sorting-associated protein 36; ESCRT-II complex subunit VPS36; Eap45; 1700010A24Rik; 2210415M20Rik; 2810408E15Rik
• Gene ID: 70160
• mRNA Refseq: NM_027338
• Protein Refseq: NP_081614
• UniProt ID: Q91XD6