Recombinant Mouse Wdfy2 Protein, Myc/DDK-tagged

• Cat.No.: Wdfy2-6970M
• Product Overview: Purified recombinant protein of Mouse WD repeat and FYVE domain containing 2 (Wdfy2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates. Participates in transferrin receptor endocytosis.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 45.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Wdfy2 WD repeat and FYVE domain containing 2 [ Mus musculus (house mouse) ]
• Official Symbol: Wdfy2
• Synonyms: Wdfy2; WD repeat and FYVE domain containing 2; ProF; ZFYVE22; 5830485M08; B130024L21Rik; WD repeat and FYVE domain-containing protein 2; WD40- and FYVE domain-containing protein 2; propeller-FYVE protein
• Gene ID: 268752
• mRNA Refseq: NM_175546
• Protein Refseq: NP_780755
• UniProt ID: Q8BUB4