Recombinant Mouse Wdr26 Protein, Myc/DDK-tagged

• Cat.No.: Wdr26-6976M
• Product Overview: Purified recombinant protein of Mouse WD repeat domain 26 (Wdr26), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria. Protects also cells by promoting hypoxia-mediated autophagy and mitophagy.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 70.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Wdr26 WD repeat domain 26 [ Mus musculus (house mouse) ]
• Official Symbol: Wdr26
• Synonyms: WDR26; WD repeat domain 26; WD repeat-containing protein 26; C77982; AA693241; AI447817; AU044014; 1600024A01Rik
• Gene ID: 226757
• mRNA Refseq: NM_145514
• Protein Refseq: NP_663489
• UniProt ID: Q8C6G8