Recombinant Mouse Wnk4 Protein, Myc/DDK-tagged

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Recombinant Mouse Wnk4 Protein, Myc/DDK-tagged

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Cat.No. : Wnk4-7004M
Product Overview : Purified recombinant protein of Mouse WNK lysine deficient protein kinase 4 (Wnk4), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K+ channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K+ secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 132.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Wnk4 WNK lysine deficient protein kinase 4 [ Mus musculus (house mouse) ]
Official Symbol : Wnk4
Synonyms : WNK4; WNK lysine deficient protein kinase 4; serine/threonine-protein kinase WNK4; protein kinase with no lysine 4; protein kinase lysine-deficient 4; protein kinase, lysine deficient 4; Pha2b; Prkwnk4; 2010002J11Rik
Gene ID : 69847
mRNA Refseq : NM_175638
Protein Refseq : NP_783569
UniProt ID : Q80UE6

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