Recombinant Murine Interleukin 12a, P35-P40 Il12a-211M

Recombinant Murine Interleukin 12a, P35-P40


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Recombinant Murine Interleukin 12a, P35-P40

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Cat.No. : Il12a-211M Optional Service: Optional requirements on this protein
Product Overview : Recombinant Murine IL-12 is a disulfide linked heterodimeric protein with a molecular weight of 75 kDa comprised of disulfide-bonded 35 kDA (p35) and 40 kDa (p40) subunits. It is expressed inCHO cells.
Description : Interleukin 12 (IL-12) is a regulatory protein produced by activated B lymphocytes and macrophages. The biological activities of IL-12 include the stimulation of growth of activated CD4+ and CD8+ T cells and NK cells. Human IL-12 also promotes the development of proinflammatory/TH1-like CD4+ cells and cytotoxic CD8+T cells.
Source : CHO cells.
Purity : Greater than 98% (determined by SDS-PAGE and HPLC analysis).
Specific Activity : ≥ 1 x10⁷ IU/mg.
Endotoxin Level : < 0.1 ng per µg of rMu IL-12 (1EU/µg).
Biological Activity : The ED₅₀ as determined by the dose-dependent stimulation of INF-( production by murine splenocytes co-stimulated with IL-18 is ≤ 0.1 ng / ml, corresponding to a specific activity of ≥ 1 x10⁷ units/mg.
Formulation : Lyophilized from a sterile-filtered protein solution in 0.5 x PBS (pH 7.2).
Reconstitution : Please Note: Always centrifuge product before opening vial. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can than be diluted into other aqueous buffers and stored at -20°C for future use.
Storage : The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted murine IL-12 should be used immediately or stored long-term in undiluted working aliquots at -20°C. Avoid repeated freeze / thaw cycles.
PDB rendering based on 1f45. :

Gene Name : Il12a interleukin 12a [ Mus musculus ]
Synonyms : Il12a; interleukin 12a; p35; Ll12a; Il-12a; IL-12p35; MGC151228; MGC151232; interleukin 12a p35 subunit; interleukin 12a
Gene ID : 16159
mRNA Refseq : NM_001159424
Protein Refseq : NP_001152896
UniProt ID : P43431
Chromosome Location : 3 E1; 3 37.0 cM
Pathway : Allograft rejection; Cytokine-cytokine receptor interaction; RIG-I-like receptor signaling pathway; Jak-STAT signaling pathway; Toll-like receptor signaling pathway; Type I diabetes mellitus
Function : cytokine activity; growth factor activity; interleukin-12 beta subunit binding; interleukin-12 receptor binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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