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Recombinant Ovine Prion Protein, His-tagged

Cat.No. : Prnp-797O
Product Overview : Recombinant Ovine Prion Protein (Genotype: ARE (Codons 136,154,171)) was expressed in E. coli with His tag.
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Description : N-terminal His-tagged full-length mature PrPc. The protein may be reconstituted in detergent-containing buffers e.g. TX-100 (0.5%) or under mild denaturing conditions (e.g. 1.5 M guanidine-HCl or urea). The His-PrPc is an ideal positive control in immunochemical detection of prions. It may be used directly for the production of antibodies in animals.
Source : E. coli
Species : Ovine
Tag : His
Form : Lyophilized from 10 mM Tris-HCl pH 6.7
Purity : > 95 % (SDS-PAGE)
Storage : Store at -80 centigrade, avoid freeze/thaw cycles.
Gene Name : PRNP prion protein [ Ovis aries (sheep) ]
Official Symbol : Prnp
Synonyms : Prp; SIP; PRPC
Gene ID : 493887
mRNA Refseq : NM_001009481.1
Protein Refseq : NP_001009481.1
UniProt ID : P23907

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the role of PRNP in the treatment of neurodegenerative diseases? 04/02/2022

Regulating the expression level of PRNP can influence the development of neurodegenerative diseases and the treatment effect. For example, certain drugs can inhibit the death of neurons and slow the progression of the disease by inhibiting the expression level of PRNP.

How does PRNP relate to other biomarkers? 06/09/2021

PRNP has some association with other biomarkers. For example, in Creutzkok disease, abnormal folding and aggregation of PRNP proteins can be used with biomarkers such as amyloid to assess the diagnosis and prognosis of the disease.

Why is the expression level of RNP diagnostic and prognostic for neurodegenerative diseases? 11/20/2020

PRNP expression levels can be used to aid in diagnosing neurodegenerative diseases and assessing prognosis. For example, in Alzheimer's disease, detecting mutations in the PRNP gene can predict disease development and prognosis.

How to use mutation or abnormal expression of PRNP for disease diagnosis and prognosis assessment? 06/14/2020

It can be used to aid in diagnosing neurological diseases and assessing prognosis by detecting mutations and expression levels of the PRNP gene. For example, in Creutzkok disease, detecting mutations in the PRNP gene can predict the diagnosis and prognosis of the disease.

How are PRNP expression levels related to neurodegenerative diseases? 01/24/2020

The expression level of PRNP is associated with the occurrence and progression of neurodegenerative diseases. For example, in Alzheimer's disease and Parkinson's disease, PRNP expression levels can change and may contribute to the development of the disease.

Which diseases are PRNP mutations or abnormalities associated with? 05/11/2019

Mutations or abnormal expression of PRNP may be associated with a variety of neurological disorders. For example, in Creutzkok disease, mutations in the PRNP gene lead to abnormal protein folding and aggregation, which in turn causes the disease. In addition, in diseases such as Alzheimer's disease and Parkinson's disease, PRNP expression levels may also change and promote the development of the disease.

Customer Reviews (3)

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Reviews
02/15/2020

    PRNP showed good solubility in Western blot and could be easily dissolved in various buffers.

    04/25/2019

      The stability of PRNP was still very good under different environmental conditions, indicating its wide applicability and stability.

      04/12/2019

        Using PRNP for experiments, I can perform experimental manipulations more easily without having to worry about the reproducibility of experimental results.

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