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Prnp

  • Official Full Name

    prion protein

  • Overview

    The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein.
  • Synonyms

    PRNP; CJD; GSS; PrP; ASCR; PRIP; PrPc; CD230; prion; MGC26679; PrP27-30; PrP33-35C; prion protein; major prion protein; p27-30; CD230 antigen; prion protein PrP; OTTHUMP00000030161; OTTHUMP00000030162; OTTHUMP00000030163; OTTHUMP00000161139; prion-related protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos
  • Bovine
  • Cervid
  • Cervus elaphus
  • Chicken
  • Cynomolgus Monkey
  • Hamster
  • Human
  • Mouse
  • Ovine
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Sheep
  • E.coli
  • E.coli BL21
  • HEK293
  • HEK293F
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • Fc
  • His
  • Avi
  • hIgG1
  • hIgG4
  • His (Fc)
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRNP-1898H Recombinant Human Prion Protein, His-tagged E.coli His
Human PRNP-373H Recombinant Human PRNP, Fc-tagged Human Cell Fc Met1-Gly229
Human PRNP-7569H Recombinant Human PRNP, His-tagged E.coli His 23-230aa
Human PRNP-388H Recombinant Human PRNP Protein E.coli N/A 23-230 aa
Human PRNP-789H Recombinant Human Prion Protein, His-tagged E.coli His
Human PRNP-001HCL Recombinant Human PRNP cell lysate Human Cell N/A
Human PRNP-372H Recombinant Human PRNP Protein, His-tagged HEK293 His Lys23~Ser230
Human PRNP-118H Recombinant Human PRNP Protein, His-tagged E.coli His
Human PRNP-1198H Recombinant Human PRNP Protein, His-tagged HEK293F N-His Lys23-Ser230
Human PRNP-6005H Recombinant Human PRNP Protein (Gln91-Ser231) E.coli Tag Free Gln91-Ser231
Human PRNP-5014H Recombinant Human PRNP Protein (Met1-Ser230), C-Fc tagged Mammalian cells C-Fc Met1-Ser230
Human PRNP-12HB Recombinant Human PRNP Protein, Lys23-Ser230, C-His-Avi tagged, Biotinylated HEK293 C-His-Avi Lys23-Ser230
Mouse Prnp-1065M Recombinant Mouse Prion Protein E.coli N/A
Mouse Prnp-791M Recombinant Mouse Prion Protein, His-tagged E.coli His
Mouse Prnp-1064M Recombinant Mouse Prion Protein, Globular Domain, His-tagged E.coli His
Mouse Prnp-289M Recombinant Mouse Prnp Protein E.coli N/A 23-231 aa
Mouse PRNP-13424M Recombinant Mouse PRNP Protein Mammalian Cell His
Mouse PRNP-7129M Recombinant Mouse PRNP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PRNP-7129M-B Recombinant Mouse PRNP Protein Pre-coupled Magnetic Beads HEK293
Rat PRNP-4708R Recombinant Rat PRNP Protein Mammalian Cell His
Rat PRNP-742R Recombinant Rat PRNP Protein (29-231 aa), His-tagged E.coli His 29-231 aa
Rat Prnp-5501R Recombinant Rat Prnp protein, His-tagged Yeast His 29-231aa
Rat PRNP-4367R Recombinant Rat PRNP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PRNP-4367R-B Recombinant Rat PRNP Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey PRNP-1617R Recombinant Rhesus Monkey PRNP Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey PRNP-1616R Recombinant Rhesus Monkey PRNP Protein HEK293 N/A
Rhesus monkey PRNP-1618R Recombinant Rhesus Monkey PRNP Protein, hIgG4-tagged HEK293 hIgG4
Bos Prnp-01B Recombinant Bos PRNP Protein, His-Tagged E.coli BL21 His
Bovine Prnp-799B Recombinant Bovine Prion Protein, His-tagged E.coli His
Bovine PRNP-290B Recombinant Bovine PRNP Protein E.coli N/A 24-241 aa
Bovine Prnp-800B Recombinant Bovine Prion Protein (T194A), His-tagged E.coli His
Bovine Prnp-801B Recombinant Bovine Prion Protein (F209S), His-tagged E.coli His
Bovine Prnp-802B Recombinant Bovine Prion Protein (Q228R), His-tagged E.coli His
Bovine Prnp-803B Recombinant Bovine Prion Protein (A144V), His-tagged E.coli His
Cervid PRP-01C Recombinant Cervid PRNP Protein, His-tagged E.coli His
Cervid PRP-02C Recombinant Cervid PRNP protein, His-tagged E.coli His
Cervus elaphus PRNP-40C Recombinant Cervus elaphus PRNP Protein, His-tagged E.coli His
Cynomolgus Monkey PRNP-812C Recombinant Cynomolgus PRNP Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey PRNP-555C Recombinant Cynomolgus Monkey PRNP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey PRNP-555C-B Recombinant Cynomolgus Monkey PRNP Protein Pre-coupled Magnetic Beads HEK293
Hamster Prnp-653H Recombinant Hamster Prnp Protein, His-tagged E.coli His 23-231 aa
Hamster Prnp-794H Recombinant Hamster Prion Protein, His-tagged E.coli His
Hamster Prnp-654H Recombinant Hamster Prnp Protein, His-tagged E.coli His 90-231 aa
Hamster Prnp-191H Recombinant Hamster Prnp Protein E.coli N/A 23-231 aa
Ovine Prnp-797O Recombinant Ovine Prion Protein, His-tagged E.coli His
Rhesus Macaque PRNP-3617R Recombinant Rhesus monkey PRNP Protein, His-tagged Mammalian Cell His
Rhesus Macaque PRNP-3435R Recombinant Rhesus Macaque PRNP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRNP-3435R-B Recombinant Rhesus Macaque PRNP Protein Pre-coupled Magnetic Beads HEK293
Sheep PRNP-652S Recombinant Sheep PRNP Protein, His-tagged E.coli His 25-233 aa
Chicken PRNP-7014C Recombinant Chicken PRNP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Prnp Related Articles

Prnp involved in several pathways and played different roles in them. We selected most pathways Prnp participated on our site, such as Prion diseases, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prnp were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Prion diseasesSOD1;MAP2K2;C8A;HSPA5;MAPK3;LOC100033925;IL6;C1QC;PRKACB

Prnp has several biochemical functions, for example, ATP-dependent protein binding, chaperone binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Prnp itself. We selected most functions Prnp had, and list some proteins which have the same functions with Prnp. You can find most of the proteins on our site.

Function Related Protein
ATP-dependent protein bindingPRNP;STX1A;DDX39B;DNAJC5;MYO5A;SAE1
chaperone bindingPACRG;HSPA5;AMFR;ATP1A3;DNAJB4;TFRC;TIMM9;BAX;GET4
copper ion bindingHEPHL1;TYR;ABHD1;S100U;LOXL1;AOC1;LOXL5A;P2RX2;MT3
identical protein bindingERBB2;TRIM23;SIAH1;ATG101;C1QTNF9;SHMT2;BCHE;TP63;APOH
ion channel bindingRNF207;KCNB2;KCNQ1;ARRB1;SUMO1;ACTN2;ACTN4;RANGRF;DLG1
microtubule bindingAPC;SKA2;NEIL2;APC2;NDEL1B;FES;KIF26A;NDRG1;PRC1B
protein bindingFHIT;DPP3;SIN3B;C1R;ADRA2B;SECISBP2;VTI1B;DNMT1;NR4A1
tubulin bindingSTMN1A;BRCA1;BIRC5;PARK2;AGBL1;MTAP4;ALDOA;AGBL4;ATF5

Prnp has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prnp here. Most of them are supplied by our site. Hope this information will be useful for your research of Prnp.

APP

Didonna, A; Venturini, AC; et al. Characterization of four new monoclonal antibodies against the distal N-terminal region of PrPC. PEERJ 3:-(2015).
Salazar, E; Berriatua, E; et al. Lack of relationship between Visna/maedi infection and scrapie resistance genetic markers. SPANISH JOURNAL OF AGRICULTURAL RESEARCH 12:676-682(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the role of PRNP in the treatment of neurodegenerative diseases? 04/02/2022

Regulating the expression level of PRNP can influence the development of neurodegenerative diseases and the treatment effect. For example, certain drugs can inhibit the death of neurons and slow the progression of the disease by inhibiting the expression level of PRNP.

How does PRNP relate to other biomarkers? 06/09/2021

PRNP has some association with other biomarkers. For example, in Creutzkok disease, abnormal folding and aggregation of PRNP proteins can be used with biomarkers such as amyloid to assess the diagnosis and prognosis of the disease.

Why is the expression level of RNP diagnostic and prognostic for neurodegenerative diseases? 11/20/2020

PRNP expression levels can be used to aid in diagnosing neurodegenerative diseases and assessing prognosis. For example, in Alzheimer's disease, detecting mutations in the PRNP gene can predict disease development and prognosis.

How to use mutation or abnormal expression of PRNP for disease diagnosis and prognosis assessment? 06/14/2020

It can be used to aid in diagnosing neurological diseases and assessing prognosis by detecting mutations and expression levels of the PRNP gene. For example, in Creutzkok disease, detecting mutations in the PRNP gene can predict the diagnosis and prognosis of the disease.

How are PRNP expression levels related to neurodegenerative diseases? 01/24/2020

The expression level of PRNP is associated with the occurrence and progression of neurodegenerative diseases. For example, in Alzheimer's disease and Parkinson's disease, PRNP expression levels can change and may contribute to the development of the disease.

Which diseases are PRNP mutations or abnormalities associated with? 05/11/2019

Mutations or abnormal expression of PRNP may be associated with a variety of neurological disorders. For example, in Creutzkok disease, mutations in the PRNP gene lead to abnormal protein folding and aggregation, which in turn causes the disease. In addition, in diseases such as Alzheimer's disease and Parkinson's disease, PRNP expression levels may also change and promote the development of the disease.

Customer Reviews (3)

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Reviews
02/15/2020

    PRNP showed good solubility in Western blot and could be easily dissolved in various buffers.

    04/25/2019

      The stability of PRNP was still very good under different environmental conditions, indicating its wide applicability and stability.

      04/12/2019

        Using PRNP for experiments, I can perform experimental manipulations more easily without having to worry about the reproducibility of experimental results.

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