Prnp
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Official Full Name
prion protein
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Overview
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. -
Synonyms
PRNP; CJD; GSS; PrP; ASCR; PRIP; PrPc; CD230; prion; MGC26679; PrP27-30; PrP33-35C; prion protein; major prion protein; p27-30; CD230 antigen; prion protein PrP; OTTHUMP00000030161; OTTHUMP00000030162; OTTHUMP00000030163; OTTHUMP00000161139; prion-related protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos
- Bovine
- Cervid
- Cervus elaphus
- Chicken
- Cynomolgus Monkey
- Hamster
- Human
- Mouse
- Ovine
- Rat
- Rhesus Macaque
- Rhesus monkey
- Sheep
- E.coli
- E.coli BL21
- HEK293
- HEK293F
- Human Cell
- Mammalian Cell
- Mammalian cells
- Yeast
- C
- Fc
- His
- Avi
- hIgG1
- hIgG4
- His (Fc)
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- Prnp Related Articles
Prnp involved in several pathways and played different roles in them. We selected most pathways Prnp participated on our site, such as Prion diseases, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prnp were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Prion diseases | SOD1;MAP2K2;C8A;HSPA5;MAPK3;LOC100033925;IL6;C1QC;PRKACB |
Prnp has several biochemical functions, for example, ATP-dependent protein binding, chaperone binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Prnp itself. We selected most functions Prnp had, and list some proteins which have the same functions with Prnp. You can find most of the proteins on our site.
Function | Related Protein |
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ATP-dependent protein binding | PRNP;STX1A;DDX39B;DNAJC5;MYO5A;SAE1 |
chaperone binding | PACRG;HSPA5;AMFR;ATP1A3;DNAJB4;TFRC;TIMM9;BAX;GET4 |
copper ion binding | HEPHL1;TYR;ABHD1;S100U;LOXL1;AOC1;LOXL5A;P2RX2;MT3 |
identical protein binding | ERBB2;TRIM23;SIAH1;ATG101;C1QTNF9;SHMT2;BCHE;TP63;APOH |
ion channel binding | RNF207;KCNB2;KCNQ1;ARRB1;SUMO1;ACTN2;ACTN4;RANGRF;DLG1 |
microtubule binding | APC;SKA2;NEIL2;APC2;NDEL1B;FES;KIF26A;NDRG1;PRC1B |
protein binding | FHIT;DPP3;SIN3B;C1R;ADRA2B;SECISBP2;VTI1B;DNMT1;NR4A1 |
tubulin binding | STMN1A;BRCA1;BIRC5;PARK2;AGBL1;MTAP4;ALDOA;AGBL4;ATF5 |
Prnp has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prnp here. Most of them are supplied by our site. Hope this information will be useful for your research of Prnp.
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- Q&As
- Reviews
Q&As (6)
Ask a questionRegulating the expression level of PRNP can influence the development of neurodegenerative diseases and the treatment effect. For example, certain drugs can inhibit the death of neurons and slow the progression of the disease by inhibiting the expression level of PRNP.
PRNP has some association with other biomarkers. For example, in Creutzkok disease, abnormal folding and aggregation of PRNP proteins can be used with biomarkers such as amyloid to assess the diagnosis and prognosis of the disease.
PRNP expression levels can be used to aid in diagnosing neurodegenerative diseases and assessing prognosis. For example, in Alzheimer's disease, detecting mutations in the PRNP gene can predict disease development and prognosis.
It can be used to aid in diagnosing neurological diseases and assessing prognosis by detecting mutations and expression levels of the PRNP gene. For example, in Creutzkok disease, detecting mutations in the PRNP gene can predict the diagnosis and prognosis of the disease.
The expression level of PRNP is associated with the occurrence and progression of neurodegenerative diseases. For example, in Alzheimer's disease and Parkinson's disease, PRNP expression levels can change and may contribute to the development of the disease.
Mutations or abnormal expression of PRNP may be associated with a variety of neurological disorders. For example, in Creutzkok disease, mutations in the PRNP gene lead to abnormal protein folding and aggregation, which in turn causes the disease. In addition, in diseases such as Alzheimer's disease and Parkinson's disease, PRNP expression levels may also change and promote the development of the disease.
Customer Reviews (3)
Write a reviewPRNP showed good solubility in Western blot and could be easily dissolved in various buffers.
The stability of PRNP was still very good under different environmental conditions, indicating its wide applicability and stability.
Using PRNP for experiments, I can perform experimental manipulations more easily without having to worry about the reproducibility of experimental results.
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