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Recombinant Rat AGTR2 Protein (1-45 aa), GST-tagged

Cat.No. : AGTR2-313R
Product Overview : Recombinant Rat AGTR2 Protein (1-45 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Protein Description: Partial.
  • Specification
  • Gene Information
  • Related Products
Description : Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
Source : E. coli
Species : Rat
Tag : GST
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 31.9 kDa
Protein length : 1-45 aa
AA Sequence : MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLE
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
Gene Name : Agtr2 angiotensin II receptor, type 2 [ Rattus norvegicus ]
Official Symbol : AGTR2
Synonyms : AGTR2; AT2; AT2R; AT2-R;
Gene ID : 24182
mRNA Refseq : NM_012494
Protein Refseq : NP_036626

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Are there any epigenetic modifications associated with AGTR2 expression? 05/08/2022

Epigenetic modifications, such as DNA methylation and histone acetylation, have been implicated in regulating AGTR2 expression. Hypermethylation of the AGTR2 gene promoter has been observed in certain pathological conditions, suggesting a potential mechanism for altered AGTR2 expression and associated diseases.

How does AGTR2 impact cardiac remodeling after myocardial infarction? 09/24/2021

AGTR2 activation can exert anti-fibrotic and anti-hypertrophic effects in the heart after myocardial infarction. AGTR2 activation promotes cardiomyocyte survival, limits adverse remodeling, and improves cardiac function, indicating its therapeutic potential in post-MI cardiac remodeling.

How does AGTR2 interact with other signaling pathways? 09/08/2021

AGTR2 can cross-talk with other receptors and signaling pathways, such as the insulin-like growth factor 1 receptor and the Wnt/β-catenin pathway, to regulate cellular processes.

How is AGTR2 regulated at the transcriptional level? 05/20/2021

Several transcription factors, including Sp1, AP-1, and NF-κB, can bind to the promoter region of AGTR2 and modulate its gene expression.

How is AGTR2 involved in cancer biology? 04/02/2020

AGTR2 may have dual roles in cancer progression, acting as a tumor suppressor or a promoter depending on the specific cancer type.

What post-translational modifications are known to regulate AGTR2 activity? 02/19/2020

Phosphorylation, ubiquitination, and glycosylation are among the post-translational modifications that can modulate AGTR2 function and signaling.

Are there any genetic polymorphisms associated with AGTR2? 02/03/2020

Yes, certain genetic variations in AGTR2 have been linked to various diseases, including hypertension, preeclampsia, and neurological disorders.

What are the downstream signaling pathways activated by AGTR2? 09/01/2019

AGTR2 can activate multiple signaling pathways, including phosphatases, kinases, and nitric oxide synthase.

What are the tissue-specific expression patterns of AGTR2? 01/14/2019

AGTR2 is expressed in various tissues, including the cardiovascular system, brain, kidney, and reproductive organs.

What is the role of AGTR2 in the cardiovascular system? 07/07/2018

AGTR2 has been implicated in cardiovascular development, blood pressure regulation, and vascular remodeling.

Customer Reviews (5)

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Reviews
03/12/2022

    It worked seamlessly in my experiments, yielding consistent and reliable results.

    06/25/2021

      The protein I purchased exceeded my expectations. It was highly pure and performed exceptionally well in my protein-protein interaction studies.

      02/14/2020

        I highly recommend this product. It saved me a significant amount of time and effort in my research, delivering excellent performance.

        09/08/2019

          It was easy to use, and the results were reproducible, giving me confidence in my data.

          11/30/2018

            Exceptional protein. Worth every penny.

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