Recombinant Rat Cx3cl1 Chemokine (C-X3-C Motif) Ligand 1

• Cat.No.: Cx3cl1-128R

Specification

• Cat. No.: Cx3cl1-128R
• Description: Fractalkine (FKN) is a transmembrane mucin-chemokine hybrid molecule expressed on activated endothelium that mediates attachment and firm adhesion of T cells, monocytes and NK cells. FKN plays an important proinflammatory role in rheumatoid arthritis (RA) pathogenesis as characterized by induction of synovial angiogenesis, chemotaxis, activation of monocytes and T cells as well as the stimulation of proliferation and synthesis of matrix degrading enzymes (matrix metalloproteinases, MMP) in synovial fibroblasts. Fractalkine thus may represent a novel target molecule for therapeutic intervention in RA. FKN is also an essential biomarker for predicting the prognosis of patients with colorectal cancer (CRC).
• Molecular Weight: The predicted molecular weight of Recombinant Rat Fractalkine is Mr 33 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 100 kDa.
• Source: Sf 21 Insect Cells.
• State Of Matter: Lyophilized.
• Purity: >97% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Cx3cl1 chemokine (C-X3-C motif) ligand 1 [ Rattus norvegicus ]
• Synonyms: Cx3cl1; chemokine (C-X3-C motif) ligand 1; Cx3c; Scyd1; fractalkine; small inducible cytokine subfamily D, 1; small inducible cytokine subfamily D 1
• Gene ID: 89808
• mRNA Refseq: NM_134455
• Protein Refseq: NP_604450
• UniProt ID: O55145
• Chromosome Location: 19p12
• Pathway: Chemokine signaling pathway; Cytokine-cytokine receptor interaction
• Function: chemokine activity