Recombinant Rat CXCL9 (MIG)

• Cat.No.: CXCL9-93R
• Product Overview: Rat CXCL9/MIG was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.

Specification

• Description: Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family. It is also commonly known as Monokine Induced by Gamma interferon (MIG). CXCL9 (MIG) is a T-cell chemoattractant, which is induced by IFN-gamma. It is closely related to two other CXC chemokines -CXCL10 and CXCL11. There have been 17 different C-X-C chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. CXCL9 (MIG) elicits its effects by binding to the cell surface chemokine receptor CXCR3.
• Source: Yeast
• Species: Rat
• Form: Lyophilized
• Molecular Mass: 12.0 kDa
• AA Sequence: TLVIRNQRCS CISTSQGTFH YKSLKDLKQF APSPNCNKTE IIATLKNGDQ TCLDPDSARV KKLMKEWEKK ISQKKKQKRG KNHQRSKKTR KAKTPHHPES KKTA (104)
• Applications: The rat CXCL9/MIG protein can be used in cell culture, as a CXCL9/MIG ELISA Standard, and as a Western Blot Control.
• Storage: -20 C

Gene Information

• Gene Name: Cxcl9 chemokine (C-X-C motif) ligand 9 [ Rattus norvegicus ]
• Official Symbol: CXCL9
• Synonyms: CXCL9; chemokine (C-X-C motif) ligand 9; C-X-C motif chemokine 9; small inducible cytokine B9; monokine induced by gamma interferon; Mig; Scyb9; MGC105312
• Gene ID: 246759
• mRNA Refseq: NM_145672
• Protein Refseq: NP_663705
• Pathway: Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem
• Function: CXCR3 chemokine receptor binding; chemokine activity

Reviews

02/21/2023

Customer service promptly feedback my requests, technical staff timely solve the problems that arise.

04/01/2022

The protein composition was stable and the concentration was high, which allowed me to obtain satisfactory experimental results.

Q&As

What is the relationship between CXCL9 and the chemokine receptor CXCR3?

CXCL9 can bind specifically to CXCR3 and accumulate at sites of inflammation, thereby inducing and exacerbating the inflammatory response.

Do you offer CXCL9 fused with other tags?

Yes, we will provide you with the most suitable labels according to your experimental needs.

Can CXCL9 be detected in lymphoid tissue under normal physiological conditions?

No, CXCL9 can only be detected when the organism is inflamed or infected.

CXCL9 is secreted by which cells?

CXCL9 is mainly secreted by endothelial cells and monocytes.

What diseases has CXCL9 been closely associated with the study of?

CXCL9 has been linked to pulmonary embolism, asthma and breast cancer research.