Recombinant Rat EFNA1 Protein (18-182 aa), His-tagged
Cat.No. : | EFNA1-1383R |
Product Overview : | Recombinant Rat EFNA1 Protein (18-182 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Full Length of Mature Protein. |
- Specification
- Gene Information
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Description : | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assbly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of bryonic neuronal growth cone and regulates dendritic spine morphogenesis. |
Source : | Yeast |
Species : | Rat |
Tag : | His |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 21.4 kDa |
Protein length : | 18-182 aa |
AA Sequence : | ADRHIVFWNSSNPKFREEDYTVHVQ LNDYLDIICPHYEDDSVADAAMERY TLYMVEHQEYVTCEPQSKDQVRWKC NQPSAKHGPEKLSEKFQRFTPFTLG KEFKEGHSYYYISKPIYHQETQCLK LKVTVNGKITHSPHAHANPQEKRLQ ADDPEVQVLHSIGHS |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with reconstitution instruction is sent along with the products. |
Gene Name : | Efna1 ephrin A1 [ Rattus norvegicus ] |
Official Symbol : | EFNA1 |
Synonyms : | EFNA1; ephrin A1; ephrin-A1; LERK-1; B61; |
Gene ID : | 94268 |
mRNA Refseq : | NM_053599 |
Protein Refseq : | NP_446051 |
UniProt ID : | P97553 |
Products Types
◆ Recombinant Protein | ||
Efna1-7438R | Active Recombinant Rat Efna1 protein(Met1-His181), His-tagged | +Inquiry |
EFNA1-1386H | Recombinant Human EFNA1 Protein, MYC/DDK-tagged | +Inquiry |
Efna1-3264M | Active Recombinant Mouse Efna1 protein(Met1-Ser182), hFc-tagged | +Inquiry |
Efna1-2753M | Recombinant Mouse Efna1 Protein, Myc/DDK-tagged | +Inquiry |
Efna1-3314M | Active Recombinant Mouse Efna1 protein(Met1-Ser182), His-tagged | +Inquiry |
◆ Lysates | ||
EFNA1-1514RCL | Recombinant Rat EFNA1 cell lysate | +Inquiry |
EFNA1-2177MCL | Recombinant Mouse EFNA1 cell lysate | +Inquiry |
EFNA1-2594HCL | Recombinant Human EFNA1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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