Recombinant Rat Mmp2 protein, His-tagged

Cat.No. : Mmp2-246R
Product Overview : Recombinant Rat Mmp2 fused with His tag was expressed in E. coli.
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Description : Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.
Source : E. coli
Species : Rat
Tag : His
Form : Lyophilized from sterile PBS, pH 7.4
Purity : > 95 % as determined by SDS-PAGE
Storage : Store at -70 centigrade. Avoid repeated freeze/thaw cycles.
Gene Name : Mmp2 matrix metallopeptidase 2 [ Rattus norvegicus ]
Official Symbol : Mmp2
Synonyms : MMP2; matrix metallopeptidase 2; 72 kDa type IV collagenase; MMP-2; gelatinase A; 72 kDa gelatinase; matrix metalloproteinase 2; matrix metalloproteinase-2;
Gene ID : 81686
mRNA Refseq : NM_031054
Protein Refseq : NP_112316
UniProt ID : P33436
Chromosome Location : 19p11
Pathway : Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; GnRH signaling pathway, organism-specific biosystem; GnRH signaling pathway, conserved biosystem; IL-3 Signaling Pathway, organism-specific biosystem; Leukocyte transendothelial migration, organism-specific biosystem; Leukocyte transendothelial migration, conserved biosystem;
Function : fibronectin binding; metal ion binding; metalloendopeptidase activity; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to regulate the activity of MMP2 in tumor therapy? 10/20/2022

The activity of MMP2 is regulated by inhibitors and antibodies against it to inhibit tumor metastasis and invasion.

How is MMP2 related to metastases that promote disease progression? 05/04/2022

MMP2 interacts with some transfer factors, such as VEGF and EGF, to promote tumor metastasis and invasion.

What are the application prospects of MMP2 inhibitors? 02/20/2022

Inhibitors of MMP2 can be used as potential drug targets for the treatment of tumors, cardiovascular diseases and other related diseases.

Does MMP2 interact with the tumor microenvironment? 09/15/2021

MMP2 interacts with tumor cells, immune cells, blood vessels, etc. in the tumor microenvironment to affect tumor progression and treatment effect.

What is the role of MMP2 in embryonic development? 10/18/2020

It is involved in important processes such as morphogenesis, organ development and intraembryonic lymphatic vessel formation during embryonic development.

What are the effects of MMP2 mutations in human disease? 10/13/2020

Mutations in MMP2 may affect its protein structure and function, leading to the occurrence and progression of related diseases.

Customer Reviews (3)

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06/19/2021

    The solubility and ion exchange ability are very good, which is convenient for subsequent experimental treatment and purification.

    05/13/2021

      Kinetic parameters such as enzymatic reaction rate and binding affinity were tested in the early stage, and it was found that the protein performed well.

      03/16/2021

        MMP2 products undergo strict quality control to ensure the consistency and stability of each batch.

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