Recombinant Rat Mmp2 protein, His-tagged
Cat.No. : | Mmp2-246R |
Product Overview : | Recombinant Rat Mmp2 fused with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment. |
Source : | E. coli |
Species : | Rat |
Tag : | His |
Form : | Lyophilized from sterile PBS, pH 7.4 |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | Store at -70 centigrade. Avoid repeated freeze/thaw cycles. |
Gene Name : | Mmp2 matrix metallopeptidase 2 [ Rattus norvegicus ] |
Official Symbol : | Mmp2 |
Synonyms : | MMP2; matrix metallopeptidase 2; 72 kDa type IV collagenase; MMP-2; gelatinase A; 72 kDa gelatinase; matrix metalloproteinase 2; matrix metalloproteinase-2; |
Gene ID : | 81686 |
mRNA Refseq : | NM_031054 |
Protein Refseq : | NP_112316 |
UniProt ID : | P33436 |
Chromosome Location : | 19p11 |
Pathway : | Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; GnRH signaling pathway, organism-specific biosystem; GnRH signaling pathway, conserved biosystem; IL-3 Signaling Pathway, organism-specific biosystem; Leukocyte transendothelial migration, organism-specific biosystem; Leukocyte transendothelial migration, conserved biosystem; |
Function : | fibronectin binding; metal ion binding; metalloendopeptidase activity; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
MMP2-12H | Active Recombinant Human MMP2 Protein (115-214, 393-447) | +Inquiry |
MMP2-1419H | Recombinant Human MMP2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MMP2-5425H | Recombinant Human MMP2 Protein, GST-tagged | +Inquiry |
MMP2-3371R | Recombinant Rat MMP2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Mmp2-1784M | Recombinant Mouse Mmp2 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
MMP2-47H | Native Human MMP-2/TIMP-2 Complex | +Inquiry |
MMP2-29475TH | Native Human MMP2 | +Inquiry |
MMP2-46H | Native Human MMP-2 | +Inquiry |
◆ Lysates | ||
MMP2-2380HCL | Recombinant Human MMP2 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0320C | MMP2 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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