Recombinant Rat STAT3 Protein, His (Fc)-Avi-tagged

Cat.No. : STAT3-5437R
Product Overview : Recombinant Rat STAT3 with His (Fc)-Avi tag was expressed and purified
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Source : HEK293
Species : Rat
Tag : His (Fc)-Avi
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : ≥85% by SDS-PAGE
Stability : Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Storage Buffer : PBS buffer

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
11/17/2022

    Protein worked well in assay.

    04/21/2021

      Fast shipping, great customer service.

      02/06/2018

        Excellent purity, highly recommend.

        Q&As (7)

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        Are there any known inhibitors targeting STAT3 for therapeutic purposes? 02/01/2022

        Yes, there are several inhibitors targeting STAT3, including Stattic, S3I-201, and OPB-31121, which are being explored for their therapeutic potential in cancer and other diseases.

        Can STAT3 activation influence cell proliferation and survival? 11/16/2021

        Yes, activated STAT3 can promote cell proliferation and survival by inducing the expression of genes like cyclin D1 and Bcl-xL.

        How does STAT3 contribute to oncogenesis and tumor progression? 04/12/2021

        STAT3 can contribute to oncogenesis by promoting cell proliferation, survival, angiogenesis, and immune evasion, and by suppressing apoptosis in various cancer types.

        How can the activation of STAT3 be detected in cells? 02/24/2021

        Activation of STAT3 can be detected using Western blotting with phospho-specific antibodies that recognize the tyrosine-phosphorylated form of STAT3.

        How does STAT3 interact with other signaling pathways in the cell? 08/25/2020

        STAT3 can interact with other signaling pathways such as the MAPK, PI3K/AKT, and NF-κB pathways, leading to integrated cellular responses.

        What are the primary upstream activators of STAT3? 01/02/2019

        The primary upstream activators of STAT3 are cytokines and growth factors, especially those that signal through the Janus kinase (JAK) family, such as IL-6 and EGF.

        What role does STAT3 play in immune cell differentiation and function? 04/16/2018

        STAT3 plays a crucial role in the differentiation of Th17 cells, a subset of CD4+ T cells, and is also involved in the function of myeloid-derived suppressor cells (MDSCs) and regulatory T cells, influencing immune responses.

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