Recombinant Rhesus monkey ANAPC16 Protein, His-tagged
Cat.No. : | ANAPC16-321R |
Product Overview : | Recombinant Rhesus monkey ANAPC16 full length or partial length protein was expressed. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian Cells |
Species : | Rhesus monkey |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC. |
Storage Buffer : | PBS buffer |
Gene Name : | ANAPC16 anaphase promoting complex subunit 16 [ Macaca mulatta (Rhesus monkey) ] |
Official Symbol : | ANAPC16 |
Synonyms : | ANAPC16; anaphase-promoting complex subunit 16; |
Gene ID : | 709147 |
mRNA Refseq : | NM_001257658 |
Protein Refseq : | NP_001244587 |
MIM : | |
UniProt ID : | F6TCS8 |
Products Types
◆ Recombinant Protein | ||
ANAPC16-521M | Recombinant Mouse ANAPC16 Protein, His (Fc)-Avi-tagged | +Inquiry |
ANAPC16-149R | Recombinant Rhesus Macaque ANAPC16 Protein, His (Fc)-Avi-tagged | +Inquiry |
ANAPC16-2599Z | Recombinant Zebrafish ANAPC16 | +Inquiry |
ANAPC16-1622M | Recombinant Mouse ANAPC16 Protein | +Inquiry |
◆ Lysates | ||
ANAPC16-8866HCL | Recombinant Human ANAPC16 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (19)
Ask a questionANAPC16 is known to interact with multiple binding partners within the APC/C complex. It forms a tight complex with ANAPC2 and ANAPC10, and also interacts with ANAPC5, ANAPC7, ANAPC13, and other subunits of the complex. These interactions are essential for the stability and function of the APC/C complex.
Currently, there is limited research on the specific role of ANAPC16 dysregulation in diseases. However, dysregulation of other subunits of the APC/C complex has been associated with various diseases, including cancer and developmental abnormalities. Further research is needed to determine if ANAPC16 dysregulation contributes to any specific diseases or conditions.
To study ANAPC16, researchers commonly use techniques such as immunoprecipitation, immunofluorescence, Western blotting, and genetic manipulations like siRNA-mediated knockdown or gene editing using CRISPR/Cas9. These techniques allow researchers to investigate its interactions, localization, regulation, and functional effects.
ANAPC16, as a subunit of the APC/C complex, is essential for the proper assembly and function of the mitotic spindle. The APC/C complex targets specific proteins for degradation, thus allowing the timely progression of mitosis, including proper spindle formation and chromosome segregation.
Yes, ANAPC16 is highly conserved across diverse species, from yeast to humans. This conservation suggests its importance in fundamental cellular processes.
ANAPC16 is a small protein subunit consisting of approximately 120 amino acids. It contains an N-terminal domain and a C-terminal domain, which are thought to be involved in protein-protein interactions within the APC/C complex. The precise structural details of ANAPC16 have not been extensively studied, and further research is needed to determine its three-dimensional structure and functional domains.
ANAPC16 primarily functions within the APC/C complex, which is essential for proper cell cycle regulation. As such, its interactions with other cellular pathways are mainly indirect. However, dysregulation of the APC/C complex, including ANAPC16, has been linked to various cellular pathways, such as DNA repair, chromosomal instability, and cell proliferation, which can have broader implications in cell physiology and disease development.
ANAPC16, as part of the APC/C complex, indirectly contributes to maintaining genome stability by ensuring proper cell cycle control and chromosome segregation during mitosis. By targeting key proteins involved in DNA replication, DNA damage response, and cell cycle checkpoints for degradation, ANAPC16 helps prevent aberrant cell division and the propagation of DNA errors.
Current research has not identified specific inhibitors or activators of ANAPC16. However, it is possible that modulating the activity or stability of other subunits of the APC/C complex could indirectly affect ANAPC16 function.
There is no direct evidence linking ANAPC16 to cellular senescence or aging. However, since proper cell cycle regulation is crucial for maintaining tissue homeostasis and preventing cellular senescence, ANAPC16's involvement in cell cycle control could indirectly influence aging processes. Further research is necessary to elucidate its specific role, if any, in cellular senescence and aging.
Currently, ANAPC16 is not used as a diagnostic marker for any specific condition. However, as research advances and more is understood about its roles and dysregulation in different diseases, it might potentially be considered as a diagnostic biomarker in the future.
ANAPC16 is generally expressed in most, if not all, cell types. However, its expression may vary depending on the specific cell type and its stage in the cell cycle.
Depletion or mutation of ANAPC16 is likely to disrupt the assembly and stability of the APC/C complex, impairing its ability to regulate cell cycle transitions. This can lead to defects in cell division and potentially contribute to cellular dysfunction or diseases associated with cell cycle dysregulation.
ANAPC16's basic function is in cell cycle regulation, particularly in the progression from metaphase to anaphase. However, the APC/C complex, including ANAPC16, plays indirect roles in DNA repair mechanisms by regulating the degradation of proteins involved in the cell cycle checkpoints, DNA damage response, and DNA replication. Therefore, ANAPC16 may have an indirect influence on DNA repair processes.
Currently, the known role of ANAPC16 is primarily in cell cycle regulation as a subunit of APC/C. Further research might uncover additional functions for ANAPC16 in other cellular processes.
ANAPC16 has been shown to interact with several other subunits of the APC/C complex, including ANAPC2, ANAPC5, and ANAPC15. These interactions are important for the assembly and stability of the APC/C complex.
To date, there have been no specific genetic disorders associated with ANAPC16 mutations or dysregulation. However, mutations or dysregulation in other components of the APC/C complex have been linked to various genetic disorders, such as autosomal recessive primary microcephaly and certain types of cancer.
There is limited research on the post-translational modifications of ANAPC16 specifically. However, other subunits of the APC/C complex can undergo post-translational modifications, such as phosphorylation, acetylation, and neddylation, which can potentially affect the stability and activity of the complex. It is plausible that ANAPC16 could also be regulated through similar modifications, though further studies are required to establish this.
Targeting ANAPC16 directly for therapeutic purposes has not been extensively explored. However, since dysregulation of the APC/C complex has been linked to various diseases, including cancer, understanding ANAPC16's role within the complex may provide insights for potential therapeutic strategies in the future.
Customer Reviews (4)
Write a reviewTo summarize, the ANAPC16 protein provided by the manufacturer is of exceptional quality and perfectly aligns with my experimental requirements.
The technical support provided by the manufacturer is invaluable in resolving any potential roadblocks and optimizing the utilization of ANAPC16 protein.
This reliable supply chain management guarantees uninterrupted access to the protein, allowing me to plan and conduct my experiments with confidence and without concern for availability issues.
They actively engage with the scientific community, staying up-to-date with the latest advancements related to ANAPC16 protein and sharing this valuable information.
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