| Description : |
Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:21402738).
Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively |
| Source : |
E. coli |
| Species : |
Macaca Mulatta (Rhesus Monkey) |
| Tag : |
His |
| Form : |
Buffered aqueous solution |
| Molecular Mass : |
94.5 kDa |
| Protein length : |
822 |
| AA Sequence : |
MARWFPKTLPCDVTLDVSKNHVIVD CTDKHLTEIPGGIPTNTTNLTLTIN HIPDISPASFHRLVHLVEIDFRCNC VPIRLGSKSNMCPRRLQIKPRSFSG LTYLKSLYLDGNQLLEIPQGLPPSL QLLSLEANNIFSIRKENLTELANIE ILYLGQNCYYRNPCYVSYSIEKDAF LNLTKLKVLSLKDNNVTTVPTVLPS TLTELYLYNNMIAEIQEDDFNNLNQ LQILDLSGNCPRCYNAPFPCTPCKN NSPLQIPVNAFDALTELKVLRLHSN SLQHVPPRWFKNINNLQELDLSQNF LAKEIGDAKFLHFLPNLIQLDLSFN FELQVYRASMNLSQAFSSLKSLKIL RIRGYVFKELKSFNLSPLHNLQNLE VLDLGTNFIKIANLSMFKQFKRLKV IDLSVNKISPSGDSSEVGFCSNART SVESYEPQVLEQLYYFRYDKYARSC RFKNKEASFTSVNESCYKYGQTLDL SKNSIFFIKSSDFQHLSFLKCLNLS GNLISQTLNGSEFQPLAELRYLDFS NNRLDLLHSTAFEELRKLEVLDISS NSHYFQSEGITHMLNFTKNLKVLQK LMMNDNDISSSTSRTMESESLRTLE FRGNHLDVLWRDGDNRYLQLFKNLL KLEELDISKNSLSFLPSGVFDGMPP NLKNLSLAKNGLKSFIWEKLRYLKN LETLDLSHNQLTTVPERLSNCSRSL KNLILKNNQIRSLTKYFLQDAFQLR YLDLSSNKIQMIQKTSFPENVLNNL KMLLLHHNRFLCTCDAVWFVWWVNH TEVTIPYLATDVTCVGPGAHKGQSV ISLDLYTCELDLTNLEHHHHHH |
| Purity : |
＞95% by SDS-PAGE |
| Applications : |
Antigen for antibody production |
| Storage : |
Store it under sterile conditions at -20 to -80 ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Concentration : |
0.1 mg/ml |
| Storage Buffer : |
Solution in PBS, 0.1% SKL, pH 7.4 |
