Recombinant SARS-CoV-2 S Protein, Fc/Avi-tagged S-001S

Recombinant SARS-CoV-2 S Protein, Fc/Avi-tagged


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Recombinant SARS-CoV-2 S Protein, Fc/Avi-tagged

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Cat.No. : S-001S
Product Overview : Severe acute respiratory Coronavirus 2 Spike Glycoprotein S1 (SARS-CoV-2 Spike S1), a.a. 13-665, fused at the C-terminus of the Fc portion of human IgG1, with a C-terminal Avi-tag, expressed in a HEK293 expression system and enzymatically biotinylated using Avi-tag™ technology. Biotinylation is confirmed to be ≥90%.
Description : Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 and CLEC4M/DC-SIGNR receptors and internalization of the virus into the endosomes of the host cell induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.
Source : HEK293
Species : SARS-CoV-2
Tag : Fc/Avi
Molecular Mass : 102 kDa
Protein length : 13-665
Purity : ≥ 90%
Applications : Enzyme kinetics, screening inhibitors, and selectivity profiling
Stability : ≥ 6 months
Storage : Store at -80 centigrade
Storage Buffer : 8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Warning : Avoid freeze/thaw cycles
ACE2: SARS-CoV-2 Spike Interaction :

SDS-PAGE of Coomassie staining :

Lane 1: 4 µg SARS-CoV-2; Lane 1: Protein Marker

Gene Name : S spike glycoprotein [ SARS coronavirus Tor2 ]
Official Symbol : S
Synonyms : S; spike glycoprotein; E2; spike glycoprotein
Gene ID : 1489668
UniProt ID : P59594

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