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Recombinant SARS-CoV-2 S Protein, His-tagged

Cat.No. : S-22S
Product Overview : Recombinant 2019-nCoV S-trimer Protein is produced by our Mammalian expression system and the target gene encoding Cys15-Gln1208(D614G) is expressed with a 6His tag at the C-terminus. Proline substitutions ( K986P, V987P), and G/S substitutions (R682G, R683S, R685S) are introduced to stabilize the trimeric prefusion state of Spike protein and remove the furin cleavage site, respectively.
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Description : The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Source : Human Cells
Species : SARS-CoV-2
Tag : His
Form : Supplied as a 0.2 μm filtered solution of PBS, PH7.4.
Molecular Mass : Predicted Molecular Weight: 136.5kDa
Apparent Molecular Weight: 170-220kDa, reducing conditions.
Protein Length : Cys15-Gln1208(D614G)
AA Sequence : CVNLTTRTQLPPAYTNSFTRGVYYP DKVFRSSVLHSTQDLFLPFFSNVTW FHAI HVSGTNGTKRFDNPVLPFNDGVYFA STEKSNIIRGWIFGTTLDSKTQSLL IVNN ATNVVIKVCEFQFCNDPFLGVYYHK NNKSWMESEFRVYSSANNCTFEYVS QPF LMDLEGKQGNFKNLREFVFKNIDGY FKIYSKHTPINLVRDLPQGFSALEP LVDLP IGINITRFQTLLALHRSYLTPGDSS SGWTAGAAAYYVGYLQPRTFLLKYN ENGTI TDAVDCALDPLSETKCTLKSFTVEK GIYQTSNFRVQPTESIVRFPNITNL CPFGEV FNATRFASVYAWNRKRISNCVADYS VLYNSASFSTFKCYGVSPTKLNDLC FTNV YADSFVIRGDEVRQIAPGQTGKIAD YNYKLPDDFTGCVIAWNSNNLDSKV GGN YNYLYRLFRKSNLKPFERDISTEIY QAGSTPCNGVEGFNCYFPLQSYGFQ PTNGV GYQPYRVVVLSFELLHAPATVCGPK KSTNLVKNKCVNFNFNGLTGTGVLT ESN KKFLPFQQFGRDIADTTDAVRDPQT LEILDITPCSFGGVSVITPGTNTSN QVAVL YQGVNCTEVPVAIHADQLTPTWRVY STGSNVFQTRAGCLIGAEHVNNSYE CDI PIGAGICASYQTQTNSPGSASSVAS QSIIAYTMSLGAENSVAYSNNSIAI PTNFTI SVTTEILPVSMTKTSVDCTMYICGD STECSNLLLQYGSFCTQLNRALTGI AVEQD KNTQEVFAQVKQIYKTPPIKDFGGF NFSQILPDPSKPSKRSFIEDLLFNK VTLADA GFIKQYGDCLGDIAARDLICAQKFN GLTVLPPLLTDEMIAQYTSALLAGT ITSGW TFGAGAALQIPFAMQMAYRFNGIGV TQNVLYENQKLIANQFNSAIGKIQD SLS STASALGKLQDVVNQNAQALNTLVK QLSSNFGAISSVLNDILSRLDPPEA EVQI DRLITGRLQSLQTYVTQQLIRAAEI RASANLAATKMSECVLGQSKRVDFC GKGY HLMSFPQSAPHGVVFLHVTYVPAQE KNFTTAPAICHDGKAHFPREGVFVS NG THWFVTQRNFYEPQIITTDNTFVSG NCDVVIGIVNNTVYDPLQPELDSFK EELD KYFKNHTSPDVDLGDISGINASVVN IQKEIDRLNEVAKNLNESLIDLQEL GKYEQ LVPRGSGYIPEAPRDGQAYVRKDGE WVLLSTFLHHHHHH
Endotoxin : Less than 0.1 ng/ug (1 EU/ug).
Purity : > 95% by reducing SDS-PAGE; > 90% by reducing SEC-HPLC.
Storage : Store at ≤-70 centigrade, stable for 6 months after receipt.
Store at ≤-70 centigrade, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
Quality Statement : Purity: Greater than 95% as determined by reducing SDS-PAGE; greater than 90% as determined by reducing SEC-HPLC.
Shipping : The product is shipped on dry ice pack.
Upon receipt, store it immediately at the temperature listed below.
Gene Name : S surface glycoprotein [ Severe acute respiratory syndrome coronavirus 2 ]
Official Symbol : S
Synonyms : SARS-CoV-2 S protein; SARS-CoV-2 Spike glycoprotein; SARS-CoV-2 S glycoprotein; SARS-nCoV2 Spike glycoprotein
Gene ID : 43740568
Protein Refseq : YP_009724390.1
UniProt ID : P0DTC2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Please let me know the sequence part you deleted or the whole aa region of this peptide 08/09/2023

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