Recombinant S.Pyogenes arcA Protein, His-tagged
Cat.No. : | arcA-17S |
Product Overview : | Recombinant Streptococcus Pyogenes Arginine Deiminase produced in E.coli is a non-glycosylated, polypeptide chain having a calculated molecular mass of 47,829 Dalton. S.Pyogenes arcA is expressed with a 10xHis tag at N-terminus and purified by proprietary chromatographic techniques. |
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Description : | Streptococcus pyogenes is the cause of many significant human diseases, ranging from mild superficial skin infections to life-threatening systemic diseases. Infections usually begin in the throat or skin. The most conspicuous sign is a strawberry-like rash. Instances of mild S. pyogenes infections include pharyngitis (strep throat) and localized skin infection (impetigo). The invasion of S. pyogenes and its multiplication in the fascia can lead to necrotizing fasciitis, a life-threatening condition requiring surgery. Throat infections linked with the release of certain toxins lead to scarlet fever. Other toxigenic S. pyogenes infections may lead to potentially life-threatening streptococcal toxic shock syndrome. S. pyogenes may also cause disease in the form of post-infectious "nonpyogenic" (not associated with local bacterial multiplication and pus formation) syndromes. These autoimmune-mediated complications develop from a small percentage of infections and comprise rheumatic fever and acute post infectious glomerulonephritis. Acute glomerulonephritis (inflammation of the renal glomerulus) can arise from streptococcal pharyngitis or skin infection. |
Source : | E. coli |
Species : | S.Pyogenes |
Tag : | His |
Form : | Sterile Filtered clear solution. |
Molecular Mass : | 47.829 KDa |
Purity : | Greater than 80.0% as determined by SDS-PAGE. |
Applications : | IMMUNOLOGICAL FUNCTIONS 1. Binds IgG- and IgM- and IgA-type human antibodies. 2. Immunodot test with positive/negative sera panels. |
Storage : | Store at 4 centigrade if entire vial will be used within 2-4 weeks. Store, frozen at -20 centigrade for longer periods of time. Avoid multiple freeze-thaw cycles. |
Storage Buffer : | 20mM HEPES buffer pH-7.6, 250mM NaCl and 20% glycerol. |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (26)
Ask a questionWhile ARC's role in synaptic plasticity has been primarily studied in the context of neurological disorders, there is emerging evidence suggesting its involvement in other conditions. For instance, altered ARC expression has been observed in animal models of addiction, where it is associated with synaptic adaptations in brain areas involved in reward processing. Additionally, changes in ARC expression have been found in models of stress and depression, suggesting its potential involvement in synaptic plasticity in these non-neurological disorders.
Yes, animal models with altered ARC expression have been developed. For instance, knockout mice lacking ARC have been used to study its role in synaptic plasticity, memory formation, and neurodevelopment. These models provide valuable tools for investigating the physiological functions of ARC.
Although there are currently no therapies directly targeting ARC, the identification of ARC dysregulation in neurological disorders provides a potential avenue for therapeutic interventions. By understanding the molecular mechanisms underlying ARC dysregulation, researchers may be able to develop novel treatments aimed at restoring its normal function and improving synaptic plasticity and cognitive deficits in these disorders.
The potential use of ARC as a therapeutic target for neurodevelopmental disorders is an area of ongoing investigation. Altered ARC expression has been observed in conditions such as autism spectrum disorders, suggesting its involvement in neurodevelopmental processes. However, more research is needed to fully understand the mechanisms by which ARC dysregulation contributes to these disorders and to identify potential therapeutic strategies targeting ARC.
The potential of ARC as a biomarker for neurological disorders is still being investigated. While altered ARC expression has been observed in certain conditions, its utility as a diagnostic or prognostic biomarker is yet to be determined.
Yes, several studies have explored the role of ARC dysregulation in neurological disorders. For example, altered ARC expression has been observed in animal models of Alzheimer's disease, where it is associated with impairments in synaptic plasticity and memory. Similarly, ARC expression has been found to be dysregulated in post-mortem brain tissue from individuals with schizophrenia and autism spectrum disorders. These findings suggest that ARC may contribute to the pathophysiology of these disorders.
Manipulating ARC expression or activity may hold potential for enhancing memory formation. Animal studies have shown that increasing ARC expression can enhance memory consolidation and retrieval, while reducing ARC expression impairs memory processes. However, it is important to note that manipulating ARC is a complex task and must be approached with caution, as it could have unintended effects on other cellular processes.
At present, there are no known drugs or compounds specifically targeting ARC expression or function. However, certain pharmacological interventions, such as drugs that enhance synaptic plasticity or promote memory formation, may indirectly affect ARC expression.
ARC's role in neurodegenerative diseases is still being investigated. While studies have shown alterations in ARC expression in animal models of Alzheimer's disease, the specific contribution of ARC to neurodegenerative processes is not well understood. Further research is needed to determine the extent of ARC's involvement in neurodegenerative diseases and its potential as a therapeutic target.
ARC is broadly expressed in different brain regions, including the hippocampus, neocortex, amygdala, and striatum, which are regions involved in learning, memory, and emotion.
While ARC dysregulation has been observed in neurological disorders, it is currently unclear whether ARC could serve as a reliable biomarker for these conditions. Further research is needed to determine the specificity and sensitivity of ARC as a biomarker and to establish its potential diagnostic value.
Yes, ARC interacts with a variety of proteins involved in synaptic function and plasticity. It binds to components of the postsynaptic density, such as PSD-95 and Shank, and also interacts with molecules involved in endocytosis, protein synthesis, and cytoskeletal dynamics.
Yes, ARC is known to play a role in synaptic plasticity. It is involved in the remodeling of synapses and the modulation of synaptic strength, which are crucial processes for learning and memory.
Currently, there is limited research on measuring ARC levels in blood or CSF samples. Most studies investigating ARC expression have been performed using post-mortem brain tissue or animal models. However, as technology advances, it may become possible to develop assays that enable the measurement of ARC levels in peripheral samples. This could potentially open up new avenues for studying ARC dysregulation in neurological disorders, monitoring disease progression, and assessing response to treatments.
To the best of my knowledge, there have been no specific genetic mutations or polymorphisms in the ARC gene directly linked to neurological disorders identified at this time. However, it is possible that future studies may reveal associations between ARC gene variations and neurological conditions.
ARC's potential as a target for gene therapy approaches is still uncertain. While ARC manipulation could potentially be explored as a therapeutic strategy, further research is needed to evaluate the feasibility and safety of gene therapy targeting ARC. Additionally, the specific molecular mechanisms and pathways involved in ARC function would need to be better understood to develop effective gene therapy strategies.
Future research on ARC may focus on understanding its precise molecular mechanisms and functional interactions within neuronal circuits. Investigating the potential therapeutic applications of ARC modulation in neurological disorders may also be an important direction for future studies. Additionally, exploring ARC's role in other physiological processes, such as neurodevelopment and neuroplasticity, could provide valuable insights into its broader functions.
ARC expression is known to be developmentally regulated. It is typically more highly expressed during critical periods of brain development, such as the early postnatal period, when synaptic connections are being refined and shaped.
Currently, no genetic mutations or variations in the ARC gene have been directly linked to specific human diseases. However, dysregulation of ARC expression has been reported in neurological disorders such as Alzheimer's disease and epilepsy.
Yes, ARC expression can be influenced by various environmental factors. For example, neuronal activity, such as learning and memory tasks, can rapidly induce ARC expression. Environmental enrichment, which includes exposure to an enriched environment and increased cognitive and social stimulation, has also been shown to affect ARC expression levels. Additionally, stress and drug exposure can modify ARC expression in the brain. These findings highlight the dynamic nature of ARC expression and its susceptibility to environmental influence.
ARC plays a crucial role in memory formation by promoting the consolidation and storage of memories. It is involved in the formation of long-term potentiation (LTP) at synapses, which is a key mechanism underlying memory formation and synaptic plasticity.
As of now, there are no known drugs specifically targeting ARC. However, understanding the molecular pathways involved in regulating ARC expression and function may provide potential avenues for drug development in the future.
ARC expression is highly dynamic and can change in response to various stimuli and experiences. Past studies have shown that ARC expression can be rapidly induced in response to neuronal activity and environmental cues. However, the stability of ARC expression over longer time periods and its regulation in different cellular contexts are areas that require further investigation.
The possibility of using ARC to enhance cognitive function in healthy individuals is speculative at this stage. More research is needed to fully understand ARC's role in cognitive processes and the potential implications of artificially modulating its expression or activity.
Studying ARC can provide insights into the molecular mechanisms underlying synaptic dysfunction and cognitive deficits observed in neurological disorders. It may identify potential therapeutic targets for interventions aimed at improving synaptic plasticity and memory deficits in conditions such as Alzheimer's disease, autism spectrum disorders, and schizophrenia.
While ARC is primarily expressed in neurons, recent studies have suggested that it may have some expression in other cell types, such as glial cells. However, the functional significance of ARC expression in non-neuronal cells is not yet fully understood.
Customer Reviews (8)
Write a reviewTheir commitment to providing technical support is unparalleled, and their expertise can prove invaluable in navigating any challenges or troubleshooting that may arise during my experiments.
the manufacturer can contribute to the research process by providing top-quality arcA protein that meets rigorous standards of purity, stability, and reliability.
This unique capability to selectively bind to exposed PS simplifies the identification and quantification of different cellular populations, reducing experimental errors and enhancing accuracy.
This may include providing detailed protocols, troubleshooting guidance, and access to knowledgeable experts who can answer any inquiries or concerns.
This aspect is crucial in maintaining the scientific rigor of my studies and strengthens the validity of my research findings.
When combined with the support and quality assurance provided by the manufacturer, researchers can confidently utilize arcA protein to unravel the intricate mechanisms underlying cellular processes, ultimately advancing scientific knowledge.
Its high purity and integrity ensure reliable and reproducible results, minimizing any potential variability in my experimental outcomes.
the manufacturer's commitment to continuous improvement and innovation is evident in their constant efforts to enhance the arcA protein.
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