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Recombinant S.Pyogenes arcA Protein, His-tagged

Cat.No. : arcA-17S
Product Overview : Recombinant Streptococcus Pyogenes Arginine Deiminase produced in E.coli is a non-glycosylated, polypeptide chain having a calculated molecular mass of 47,829 Dalton. S.Pyogenes arcA is expressed with a 10xHis tag at N-terminus and purified by proprietary chromatographic techniques.
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Description : Streptococcus pyogenes is the cause of many significant human diseases, ranging from mild superficial skin infections to life-threatening systemic diseases. Infections usually begin in the throat or skin. The most conspicuous sign is a strawberry-like rash. Instances of mild S. pyogenes infections include pharyngitis (strep throat) and localized skin infection (impetigo). The invasion of S. pyogenes and its multiplication in the fascia can lead to necrotizing fasciitis, a life-threatening condition requiring surgery. Throat infections linked with the release of certain toxins lead to scarlet fever. Other toxigenic S. pyogenes infections may lead to potentially life-threatening streptococcal toxic shock syndrome. S. pyogenes may also cause disease in the form of post-infectious "nonpyogenic" (not associated with local bacterial multiplication and pus formation) syndromes. These autoimmune-mediated complications develop from a small percentage of infections and comprise rheumatic fever and acute post infectious glomerulonephritis. Acute glomerulonephritis (inflammation of the renal glomerulus) can arise from streptococcal pharyngitis or skin infection.
Source : E. coli
Species : S.Pyogenes
Tag : His
Form : Sterile Filtered clear solution.
Molecular Mass : 47.829 KDa
Purity : Greater than 80.0% as determined by SDS-PAGE.
Applications : IMMUNOLOGICAL FUNCTIONS
1. Binds IgG- and IgM- and IgA-type human antibodies.
2. Immunodot test with positive/negative sera panels.
Storage : Store at 4 centigrade if entire vial will be used within 2-4 weeks. Store, frozen at -20 centigrade for longer periods of time. Avoid multiple freeze-thaw cycles.
Storage Buffer : 20mM HEPES buffer pH-7.6, 250mM NaCl and 20% glycerol.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (26)

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Has ARC been implicated in synaptic plasticity in non-neurological disorders? 12/31/2022

While ARC's role in synaptic plasticity has been primarily studied in the context of neurological disorders, there is emerging evidence suggesting its involvement in other conditions. For instance, altered ARC expression has been observed in animal models of addiction, where it is associated with synaptic adaptations in brain areas involved in reward processing. Additionally, changes in ARC expression have been found in models of stress and depression, suggesting its potential involvement in synaptic plasticity in these non-neurological disorders.

Are there any animal models with altered ARC expression for studying its functions? 11/03/2022

Yes, animal models with altered ARC expression have been developed. For instance, knockout mice lacking ARC have been used to study its role in synaptic plasticity, memory formation, and neurodevelopment. These models provide valuable tools for investigating the physiological functions of ARC.

Are there any therapeutic strategies targeting ARC for neurological disorders? 09/23/2022

Although there are currently no therapies directly targeting ARC, the identification of ARC dysregulation in neurological disorders provides a potential avenue for therapeutic interventions. By understanding the molecular mechanisms underlying ARC dysregulation, researchers may be able to develop novel treatments aimed at restoring its normal function and improving synaptic plasticity and cognitive deficits in these disorders.

Can ARC be used as a therapeutic target for neurodevelopmental disorders? 09/08/2022

The potential use of ARC as a therapeutic target for neurodevelopmental disorders is an area of ongoing investigation. Altered ARC expression has been observed in conditions such as autism spectrum disorders, suggesting its involvement in neurodevelopmental processes. However, more research is needed to fully understand the mechanisms by which ARC dysregulation contributes to these disorders and to identify potential therapeutic strategies targeting ARC.

Can ARC be used as a biomarker for neurological disorders? 08/03/2022

The potential of ARC as a biomarker for neurological disorders is still being investigated. While altered ARC expression has been observed in certain conditions, its utility as a diagnostic or prognostic biomarker is yet to be determined.

Are there any studies that have investigated ARC dysregulation in neurological disorders? 07/13/2022

Yes, several studies have explored the role of ARC dysregulation in neurological disorders. For example, altered ARC expression has been observed in animal models of Alzheimer's disease, where it is associated with impairments in synaptic plasticity and memory. Similarly, ARC expression has been found to be dysregulated in post-mortem brain tissue from individuals with schizophrenia and autism spectrum disorders. These findings suggest that ARC may contribute to the pathophysiology of these disorders.

Can ARC be manipulated to enhance memory formation? 05/19/2022

Manipulating ARC expression or activity may hold potential for enhancing memory formation. Animal studies have shown that increasing ARC expression can enhance memory consolidation and retrieval, while reducing ARC expression impairs memory processes. However, it is important to note that manipulating ARC is a complex task and must be approached with caution, as it could have unintended effects on other cellular processes.

Are there any drugs or compounds that can modulate ARC expression or function? 02/16/2021

At present, there are no known drugs or compounds specifically targeting ARC expression or function. However, certain pharmacological interventions, such as drugs that enhance synaptic plasticity or promote memory formation, may indirectly affect ARC expression.

Does ARC have any role in neurodegenerative diseases? 09/30/2020

ARC's role in neurodegenerative diseases is still being investigated. While studies have shown alterations in ARC expression in animal models of Alzheimer's disease, the specific contribution of ARC to neurodegenerative processes is not well understood. Further research is needed to determine the extent of ARC's involvement in neurodegenerative diseases and its potential as a therapeutic target.

What brain regions express ARC? 09/06/2020

ARC is broadly expressed in different brain regions, including the hippocampus, neocortex, amygdala, and striatum, which are regions involved in learning, memory, and emotion.

Can ARC be used as a biomarker for neurological disorders? 05/14/2020

While ARC dysregulation has been observed in neurological disorders, it is currently unclear whether ARC could serve as a reliable biomarker for these conditions. Further research is needed to determine the specificity and sensitivity of ARC as a biomarker and to establish its potential diagnostic value.

Does ARC have any interactions with other proteins? 04/27/2020

Yes, ARC interacts with a variety of proteins involved in synaptic function and plasticity. It binds to components of the postsynaptic density, such as PSD-95 and Shank, and also interacts with molecules involved in endocytosis, protein synthesis, and cytoskeletal dynamics.

Is ARC involved in synaptic plasticity? 04/11/2020

Yes, ARC is known to play a role in synaptic plasticity. It is involved in the remodeling of synapses and the modulation of synaptic strength, which are crucial processes for learning and memory.

Can ARC be measured in blood or cerebrospinal fluid (CSF) samples? 10/21/2019

Currently, there is limited research on measuring ARC levels in blood or CSF samples. Most studies investigating ARC expression have been performed using post-mortem brain tissue or animal models. However, as technology advances, it may become possible to develop assays that enable the measurement of ARC levels in peripheral samples. This could potentially open up new avenues for studying ARC dysregulation in neurological disorders, monitoring disease progression, and assessing response to treatments.

Are there any known genetic mutations or polymorphisms in the ARC gene associated with neurological disorders? 09/17/2019

To the best of my knowledge, there have been no specific genetic mutations or polymorphisms in the ARC gene directly linked to neurological disorders identified at this time. However, it is possible that future studies may reveal associations between ARC gene variations and neurological conditions.

Can ARC be used as a target for gene therapy approaches? 08/25/2019

ARC's potential as a target for gene therapy approaches is still uncertain. While ARC manipulation could potentially be explored as a therapeutic strategy, further research is needed to evaluate the feasibility and safety of gene therapy targeting ARC. Additionally, the specific molecular mechanisms and pathways involved in ARC function would need to be better understood to develop effective gene therapy strategies.

What are the future directions of ARC research? 07/07/2019

Future research on ARC may focus on understanding its precise molecular mechanisms and functional interactions within neuronal circuits. Investigating the potential therapeutic applications of ARC modulation in neurological disorders may also be an important direction for future studies. Additionally, exploring ARC's role in other physiological processes, such as neurodevelopment and neuroplasticity, could provide valuable insights into its broader functions.

Is ARC only expressed during specific developmental stages? 05/19/2018

ARC expression is known to be developmentally regulated. It is typically more highly expressed during critical periods of brain development, such as the early postnatal period, when synaptic connections are being refined and shaped.

Are there any genetic mutations or variations in the ARC gene associated with human diseases? 01/14/2018

Currently, no genetic mutations or variations in the ARC gene have been directly linked to specific human diseases. However, dysregulation of ARC expression has been reported in neurological disorders such as Alzheimer's disease and epilepsy.

Can ARC expression be influenced by environmental factors? 01/14/2018

Yes, ARC expression can be influenced by various environmental factors. For example, neuronal activity, such as learning and memory tasks, can rapidly induce ARC expression. Environmental enrichment, which includes exposure to an enriched environment and increased cognitive and social stimulation, has also been shown to affect ARC expression levels. Additionally, stress and drug exposure can modify ARC expression in the brain. These findings highlight the dynamic nature of ARC expression and its susceptibility to environmental influence.

How is ARC involved in memory formation? 12/24/2017

ARC plays a crucial role in memory formation by promoting the consolidation and storage of memories. It is involved in the formation of long-term potentiation (LTP) at synapses, which is a key mechanism underlying memory formation and synaptic plasticity.

Are there any drugs that directly target ARC? 11/13/2017

As of now, there are no known drugs specifically targeting ARC. However, understanding the molecular pathways involved in regulating ARC expression and function may provide potential avenues for drug development in the future.

How stable is ARC expression over time? 11/11/2017

ARC expression is highly dynamic and can change in response to various stimuli and experiences. Past studies have shown that ARC expression can be rapidly induced in response to neuronal activity and environmental cues. However, the stability of ARC expression over longer time periods and its regulation in different cellular contexts are areas that require further investigation.

Can ARC be used for enhancing cognitive function in healthy individuals? 09/30/2017

The possibility of using ARC to enhance cognitive function in healthy individuals is speculative at this stage. More research is needed to fully understand ARC's role in cognitive processes and the potential implications of artificially modulating its expression or activity.

How can studying ARC contribute to our understanding of neurological disorders? 02/23/2017

Studying ARC can provide insights into the molecular mechanisms underlying synaptic dysfunction and cognitive deficits observed in neurological disorders. It may identify potential therapeutic targets for interventions aimed at improving synaptic plasticity and memory deficits in conditions such as Alzheimer's disease, autism spectrum disorders, and schizophrenia.

Can ARC also be found outside of neurons? 01/05/2016

While ARC is primarily expressed in neurons, recent studies have suggested that it may have some expression in other cell types, such as glial cells. However, the functional significance of ARC expression in non-neuronal cells is not yet fully understood.

Customer Reviews (8)

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Reviews
11/13/2022

    Their commitment to providing technical support is unparalleled, and their expertise can prove invaluable in navigating any challenges or troubleshooting that may arise during my experiments.

    03/25/2020

      the manufacturer can contribute to the research process by providing top-quality arcA protein that meets rigorous standards of purity, stability, and reliability.

      11/08/2019

        This unique capability to selectively bind to exposed PS simplifies the identification and quantification of different cellular populations, reducing experimental errors and enhancing accuracy.

        10/11/2019

          This may include providing detailed protocols, troubleshooting guidance, and access to knowledgeable experts who can answer any inquiries or concerns.

          07/22/2018

            This aspect is crucial in maintaining the scientific rigor of my studies and strengthens the validity of my research findings.

            03/20/2018

              When combined with the support and quality assurance provided by the manufacturer, researchers can confidently utilize arcA protein to unravel the intricate mechanisms underlying cellular processes, ultimately advancing scientific knowledge.

              07/10/2017

                Its high purity and integrity ensure reliable and reproducible results, minimizing any potential variability in my experimental outcomes.

                11/18/2016

                  the manufacturer's commitment to continuous improvement and innovation is evident in their constant efforts to enhance the arcA protein.

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