Recombinant Viral B18R Protein
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|Product Overview :||Recombinant viral B18R (His20-Glu351) protein with Fc region of human Human IgG1 (Pro100-Lys300) at N-terminus was expressed in Human embryonic kidney cell, HEK293.|
|Description :||Counteracts the antiviral effects of host IFN-alpha/beta. Acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.|
|Form :||Disulfide-linked homodimer|
|Bio-activity :||Measured by its ability to inhibit Type-I IFN-mediated anti-viral activity. The ED50 for this effect, as measured by inhibition of recombinant Human IFN‑ alpha 2, is 0.3-1.8 ng/mL.|
|Molecular Mass :||65 kDa|
|N-terminal Sequence Analysis :||Met-Asp-Pr o100|
|Endotoxin :||<0.10 EU per 1 μg of the protein by the LAL method.|
|Purity :||>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.|
|Storage :||Avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
|Storage Buffer :||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Preservative :||Reconstitute at 500 μg/mL in PBS.|
|Gene Name :||B19R temporal expression: early [ Vaccinia virus ]|
|Official Symbol :||B19R|
|Synonyms :||IFN-alpha/beta-receptor-like secreted glycoprotein; similar to VACCP-B19R; host defense modulator [VACWR-B18R]; B18R; B19R|
|Gene ID :||3707577|
|UniProt ID :||P25213|
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