Recombinant Zebrafish AGXTB

• Cat.No.: AGXTB-12378Z
• Product Overview: Recombinant Zebrafish AGXTB full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: agxtb alanine-glyoxylate aminotransferase b [ Danio rerio (zebrafish) ]
• Official Symbol: AGXTB
• Gene ID: 79378
• mRNA Refseq: NM_213162
• Protein Refseq: NP_998327
• UniProt ID: Q6PHK4

Reviews

04/09/2022

The customer support was also excellent, providing prompt assistance when needed.

09/19/2021

If you want top-notch results, this protein is the way to go!

07/14/2020

Excellent value for its price

02/28/2019

The customer service was exceptional, with prompt assistance and valuable technical support.

06/12/2018

I would appreciate more detailed documentation accompanying the product.

Q&As

What role does AGXTB play in glyoxylate metabolism?

AGXTB is crucial in maintaining glyoxylate homeostasis, preventing the accumulation of glyoxylate that could lead to oxalate formation and calcium oxalate-related kidney stone disease.

How does AGXTB function in the context of tissue-specific metabolism in the liver, kidney, and other organs?

AGXTB's expression and function may vary among different tissues, contributing to organ-specific metabolic adaptations and responses.

Can AGXTB be involved in the regulation of glyoxylate production during specific physiological conditions?

Yes, AGXTB may play a role in regulating glyoxylate production in response to certain physiological conditions, such as oxidative stress or changes in amino acid metabolism.

Can AGXTB deficiency lead to primary hyperoxaluria type 1 (PH1)?

AGXTB deficiency itself is not associated with PH1; however, perturbations in AGXTB function may indirectly impact PH1 development by influencing glyoxylate levels.

Are there any genetic variants of AGXTB associated with kidney stone disease?

Yes, certain genetic variations in the AGXTB gene have been linked to an increased risk of developing calcium oxalate kidney stones in some populations.

Does AGXTB play a role in cellular redox regulation?

AGXTB has been implicated in cellular redox balance, as glyoxylate metabolism can influence cellular reactive oxygen species (ROS) levels, affecting oxidative stress.

Can AGXTB expression be influenced by environmental factors or dietary choices?

Yes, certain dietary factors, such as vitamin B6 deficiency, have been shown to affect AGXTB activity, leading to perturbations in glyoxylate metabolism and kidney stone formation.

How is AGXTB expression regulated at the transcriptional level?

The transcriptional regulation of AGXTB involves various factors, including peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and hepatocyte nuclear factor 4-alpha (HNF-4α), which bind to specific regulatory regions of the AGXT2L1 gene.

How does AGXTB interact with other enzymes in glyoxylate metabolism pathways?

AGXTB collaborates with other enzymes, such as alanine-glyoxylate aminotransferase (AGXT), to maintain the balance between glyoxylate and glycine levels, which is essential in mitigating the risk of kidney stone formation.

How is AGXTB involved in the metabolism of other amino acids apart from glycine?

AGXTB, as an aminotransferase, participates in the interconversion of other amino acids, such as serine, alanine, and aspartate, in addition to its role in the glyoxylate-glycine pathway.