Recombinant Zebrafish AHRRB

• Cat.No.: AHRRB-3429Z
• Product Overview: Recombinant Zebrafish AHRRB full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ahrrb aryl-hydrocarbon receptor repressor b [ Danio rerio (zebrafish) ]
• Official Symbol: AHRRB
• Gene ID: 565319
• mRNA Refseq: NM_001033920
• Protein Refseq: NP_001029092
• UniProt ID: Q3T2L2

Reviews

04/09/2022

Great value for the quality received. Customer service was top-notch too.

10/06/2021

Quality product at a reasonable price. Customer service was a delight.

08/20/2020

Impressed by the affordable pricing without compromising product quality.

02/13/2019

Customer service went the extra mile, and the product exceeded expectations.

11/17/2018

I love using this recombination protein in my research. It's so easy to work with!

Q&As

Elaborate on the structural changes AHRRB undergoes upon binding to AHR?

Upon binding, AHRRB undergoes conformational changes that facilitate its interaction with co-repressors and hinder the assembly of transcriptional machinery.

What techniques can be employed to analyze AHRRB's post-translational modifications?

Techniques such as mass spectrometry and site-directed mutagenesis can be used to identify and study AHRRB's post-translational modifications.

Explain the concept of "gene crosstalk" involving AHRRB and other regulatory pathways?

Gene crosstalk refers to interactions between AHRRB and other transcriptional regulators, leading to complex modulation of gene expression networks.

How is AHRRB expression regulated, and what factors influence its transcriptional activity?

AHRRB expression can be influenced by ligands that activate AHR and other transcription factors that interact with its promoter region.

How does AHRRB's function intersect with cellular metabolic pathways?

AHRRB may influence cellular metabolism through its interactions with transcription factors involved in metabolic regulation.

Can you outline the steps involved in a chromatin immunoprecipitation (ChIP) assay to study AHRRB-DNA interactions?

Steps include crosslinking, chromatin fragmentation, immunoprecipitation, DNA purification, and subsequent analysis like qPCR or sequencing.

What are the implications of AHRRB's involvement in the regulation of AHR-mediated gene expression?

AHRRB's regulatory role can impact cellular responses to environmental toxins and endogenous ligands, influencing processes like xenobiotic metabolism and immune responses.

How does AHRRB interact with the Aryl Hydrocarbon Receptor (AHR) at the molecular level?

AHRRB competes with AHR for binding to common target DNA sequences, inhibiting AHR-mediated gene transcription by acting as a transcriptional repressor.

In laboratory settings, what techniques are employed to investigate AHRRB-AHR interactions?

Techniques such as co-immunoprecipitation, fluorescence resonance energy transfer (FRET), and protein-protein interaction assays help study AHRRB-AHR interactions.

How might AHRRB's interaction with chaperone proteins influence its stability and function?

Chaperone proteins can assist in proper folding of AHRRB, affecting its stability and ability to interact with other cellular components.