Recombinant Zebrafish ALCAMB

• Cat.No.: ALCAMB-11912Z
• Product Overview: Recombinant Zebrafish ALCAMB full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: alcamb activated leukocyte cell adhesion molecule b [ Danio rerio (zebrafish) ]
• Official Symbol: ALCAMB
• Gene ID: 323919
• mRNA Refseq: NM_212634
• Protein Refseq: NP_997799
• UniProt ID: F1QE54

Reviews

04/07/2022

The ALCAMB protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.

09/17/2021

Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.

10/10/2018

One notable advantage of the ALCAMB protein is the outstanding technical support provided by the manufacturer.

05/15/2017

Their expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.

Q&As

Can changes in the ALCAMB gene impact neural development and function?

Yes, changes in the ALCAMB gene can indeed impact neural development and function. Studies have shown that ALCAMB is involved in various aspects of neural development, such as axon guidance, neuronal migration, synapse formation, and myelination.

Is the ALCAMB protein involved in any specific biological processes?

Yes, the ALCAMB protein is involved in various biological processes. Its role in cell adhesion and migration processes is crucial for tissue development and organization. ALCAMB is important for proper axon guidance, neurite outgrowth, and neuronal connectivity in the nervous system. It is also involved in immune responses, inflammation, and leukocyte trafficking. Additionally, ALCAMB expression has been implicated in angiogenesis, wound healing, and cancer metastasis.

Are there any known alternative splicing variants of the ALCAMB gene?

Yes, alternative splicing variants of the ALCAMB gene have been identified. Alternative splicing is a process by which different combinations of exons are included or excluded from the final mRNA transcript, resulting in the production of multiple protein isoforms with distinct functions or properties. In the case of ALCAMB, alternative splicing events generate different isoforms that can vary in their extracellular domains or cytoplasmic tails. These isoforms may have differential binding affinities, cellular localizations, or signaling capabilities, potentially adding complexity to the functions of ALCAMB in different cell types or tissues.

How does ALCAMB contribute to cell adhesion and junction formation?

ALCAMB is a cell adhesion molecule that plays a crucial role in cell-cell adhesion and the formation of adherens junctions. It interacts with other ALCAM proteins on neighboring cells through homophilic binding, forming trans-interactions. These interactions facilitate the adhesion between cells, leading to the formation and stabilization of cell-cell contacts.

Does ALCAMB have any diagnostic or therapeutic potential?

ALCAMB has shown potential as a diagnostic and prognostic marker in certain diseases. Aberrant ALCAMB expression has been detected in various cancers, and its levels have been correlated with tumor progression and patient survival. ALCAMB may serve as a biomarker to aid in cancer diagnosis and prognosis.

Have any animal models or knockout studies been conducted to study the function of ALCAMB?

Yes, animal models and knockout studies have been conducted to investigate the function of ALCAMB. For example, mice with a targeted deletion of the ALCAMB gene have been generated and studied. These knockout mice exhibit defects in axon guidance, neural migration, and synapse formation, highlighting the essential role of ALCAMB in neuronal development and connectivity. Additionally, studies involving ALCAMB knockout mice have contributed to our understanding of the protein's involvement in immune responses and leukocyte trafficking.

Are there any genetic mutations or polymorphisms in the ALCAMB gene?

Limited information is available about genetic mutations or polymorphisms specifically in the ALCAMB gene. Most research has focused on the ALCAM gene, which is closely related to ALCAMB. However, it is possible that there may be genetic variations in the ALCAMB gene that have yet to be fully characterized.

Are there any specific mutations or abnormalities associated with the ALCAMB gene?

Yes, some mutations or abnormalities in the ALCAMB gene have been reported. For example, in certain cases of developmental disorders like Adams-Oliver syndrome, which affects the development of the limbs and skull, mutations in the ALCAMB gene have been identified. These mutations disrupt the normal function of ALCAMB and contribute to the symptoms of the disorder.

Where is the ALCAMB protein expressed in the body?

The ALCAMB protein is expressed in various tissues throughout the body. It is found in the nervous system, including regions of the brain such as the hippocampus, cortex, and cerebellum. It is also present in heart, lung, liver, kidney, and other organs. In addition, ALCAMB expression has been observed in cancerous tissues, suggesting its potential involvement in cancer progression.

Are there any known interacting partners of the ALCAMB protein?

Yes, the ALCAMB protein has been found to interact with several other proteins. One of its well-known binding partners is CD6, another cell adhesion molecule. The ALCAMB-CD6 interaction plays a role in immune cell activation and regulation. The ALCAMB protein has also been reported to interact with cytoskeletal components, such as actin and tubulin, suggesting its involvement in cytoskeletal rearrangements during cell migration and adhesion.

Are there any known drugs or inhibitors that specifically target ALCAMB?

Currently, there are no known drugs or inhibitors that specifically target ALCAMB. However, ongoing research aimed at understanding the function and regulation of ALCAMB may lead to the identification of potential therapeutic targets. Developing drugs or inhibitors that can selectively modulate ALCAMB activity or its interaction with other molecules could have therapeutic benefits in cancer, neurological disorders, or immune-related diseases.

Does the expression of the ALCAMB protein have clinical implications?

The expression of the ALCAMB protein has been associated with certain pathological conditions and diseases. For example, altered ALCAMB expression has been observed in various cancers, such as breast, lung, colorectal, and pancreatic cancer. Abnormal ALCAMB expression has also been linked to certain neurological disorders, including Alzheimer's disease and epilepsy. Therefore, understanding the expression and function of ALCAMB in different diseases could have potential clinical implications for diagnosis, prognosis, and the development of targeted therapies.

How is the ALCAMB protein regulated?

The regulation of ALCAMB protein expression is complex and can be influenced by various factors. Transcriptional regulation is one mechanism that controls ALCAMB expression, where the ALCAMB gene is activated or repressed by specific transcription factors. Additionally, post-transcriptional modifications, such as alternative splicing of the ALCAMB mRNA, can generate different isoforms that may have distinct functions. Protein stability, degradation, and trafficking also play a role in regulating ALCAMB protein levels and localization within cells.