Recombinant Zebrafish ALOX5A

• Cat.No.: ALOX5A-8198Z
• Product Overview: Recombinant Zebrafish ALOX5A full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: alox5a arachidonate 5-lipoxygenase a [ Danio rerio (zebrafish) ]
• Official Symbol: ALOX5A
• Gene ID: 567204
• mRNA Refseq: NM_001256747
• Protein Refseq: NP_001243676
• UniProt ID: B8A697

Reviews

12/26/2022

ALOX5A is well suited for use in our laboratory because they can be stored for a long time and maintain their original properties.

10/31/2021

The sensitivity of ALOX5A in Western blot was very high and low concentrations of the target protein could be detected.

10/30/2021

ALOX5A has a wide range of products to meet our needs in different research areas.

01/21/2021

Using ALOX5A as a catalyst, the rate and yield of chemical reactions can be significantly increased with high catalytic efficiency.

Q&As

Which diseases is ALOX5A associated with?

ALOX5A has been linked to diseases such as asthma, allergies, atherosclerosis and liver fibrosis.

What is the structure of ALOX5A?

ALOX5A belongs to the large family of proteins lipoxygenases with a similar tertiary structure, consisting of two distinct parts of the C-terminal catalytic domain and the N-terminal containing a transmembrane helical domain containing different numbers of mitochondria.

Which food is ALOX5A related to?

A high-sugar, high-fat diet can induce the expression and activity of ALOX5A and increase leukotriene synthesis.

In which cells is ALOX5A expressed?

ALOX5A is mainly expressed in white blood cells, such as neutrophils and monocytes.

What is the function of ALOX5A?

ALOX5A is an enzyme whose primary function is to catalyze the conversion of arachidonic acid into leukotrienes in various lipids.

What is the role of ALOX5A metabolite leukotriene?

Leukotriene has physiological functions such as inflammation, immune response regulation and cell proliferation.

What factors are associated with ALOX5A?

ALOX5A is related to diet, environment, genes and other factors.

Which role of ALOX5A in drug development?

ALOX5A is widely used in drug development, such as in the treatment of asthma, dermatitis, liver fibrosis, liver ® and other diseases.

What are the health effects of ALOX5A gene deletion?

Current relevant data show that the deletion of ALOX5A gene is related to obesity, diabetes, cardiovascular disease and other diseases.

Does the relationship between ALOX5A regulated signaling pathway and gene expression?

The metabolite leukotriene catalyzed by ALOX5A can affect the production of factors and physiological activities such as inflammation and immune response by regulating the expression of genes such as Cyclooxygenase-2 (COX-2) and Interleukin-8 (IL-8).

What is the target role of ALOX5A in drug development?

ALOX5A is used as a potential target in drug development and can be targeted by different compounds or molecules to regulate its function or product production.

Which signaling pathways are regulated by ALOX5A?

Leukotriene, a metabolite catalyzed by ALOX5A, can regulate physiological processes such as inflammation and immune response by activating NF-κB signaling pathway and Akt signaling pathway.