Recombinant Zebrafish APOA1A
Cat.No. : | APOA1A-8751Z |
Product Overview : | Recombinant Zebrafish APOA1A full length or partial length protein was expressed. |
- Specification
- Gene Information
- Related Products
- Download
Source : | Mammalian Cells |
Species : | Zebrafish |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | apoa1a apolipoprotein A-Ia [ Danio rerio (zebrafish) ] |
Official Symbol : | APOA1A |
Gene ID : | 30355 |
mRNA Refseq : | NM_131128 |
Protein Refseq : | NP_571203 |
UniProt ID : | O42363 |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (18)
Ask a questionResearch related specifically to therapeutic interventions targeting APOA1A protein may be limited. However, various studies focus on understanding the role of APOA1 and HDL metabolism in cardiovascular health. Therapies aimed at raising HDL levels, such as lifestyle modifications and pharmacological interventions, are areas of ongoing research.
Currently, APOA1A levels are not commonly used to predict the response to lipid-lowering therapy. Instead, other markers such as LDL cholesterol levels and genetic markers like the presence of certain gene variants are used to guide treatment decisions and assess the effectiveness of lipid-lowering therapies. However, ongoing research may shed light on the potential use of APOA1A levels as predictive markers in the future.
Currently, there are no drugs or medications specifically designed to target the APOA1A protein. However, there are medications available that can indirectly impact APOA1A levels and HDL functionality. These include statins, fibrates, and niacin, which can help increase HDL levels and promote cardiovascular health.
The APOA1A protein is a specific variant or isoform of the APOA1 protein. It may have slight differences in its genetic sequence or structure compared to the regular APOA1 protein, but it still performs similar functions in lipid transport and cardiovascular health.
Yes, there are genetic disorders associated with mutations in the APOA1A protein. One such disorder is familial amyloidosis, in which mutations in the APOA1 gene can lead to the accumulation of amyloid protein deposits in various organs, including the kidneys, liver, and heart. This condition can result in organ dysfunction and can be inherited in an autosomal dominant manner.
Currently, there are no specific drugs or interventions known to directly increase APOA1A levels. However, lifestyle modifications such as regular exercise, a healthy diet, and weight loss have been shown to increase HDL levels, which may indirectly affect APOA1A levels. Additionally, certain medications like statins, fibrates, and niacin can help increase HDL levels and may impact APOA1A levels.
Dysfunctional or deficient APOA1A protein is not known to cause specific diseases. However, alterations in APOA1 protein levels or functionality can contribute to conditions like familial hypoalphalipoproteinemia, characterized by low HDL cholesterol levels and an increased risk of cardiovascular diseases.
The APOA1A protein is a variant of the APOA1 protein and is generally present in all individuals; however, specific genetic variations may lead to differences in APOA1A isoform expression across different populations. The expression levels can also differ depending on genetic and environmental factors.
Hormone levels can influence APOA1A levels to some extent. Estrogen, for example, has been shown to increase APOA1A levels and promote HDL synthesis. In postmenopausal women, when estrogen levels decrease, there is often a decline in APOA1A levels and HDL functionality. Similarly, testosterone has been found to impact HDL metabolism and APOA1A levels in men. However, the exact mechanisms and effects of various hormones on APOA1A levels are still being explored.
While the primary role of APOA1A is related to lipid metabolism, there is emerging evidence suggesting a potential association between APOA1A and neurological disorders. Some studies have found links between APOA1A mutations and an increased risk of Alzheimer's disease, stroke, and cognitive decline. However, further research is needed to fully understand the role of APOA1A in these neurological conditions.
While the primary function of the APOA1A protein is related to lipid metabolism and its role in HDL particles, it may also have additional functions. Some studies suggest that APOA1A could have anti-inflammatory properties, antioxidant effects, and potential involvement in immune regulation, although further research is needed to fully understand these roles.
Yes, lifestyle changes can have an impact on APOA1A levels and functionality. Regular exercise, a healthy diet, weight loss, and avoiding smoking can help increase HDL levels and improve the overall functionality of the APOA1A protein. These lifestyle modifications are known to promote cardiovascular health and may positively influence HDL metabolism.
While there may be genetic variations within the APOA1 gene, resulting in different isoforms like APOA1A, there may not be specific mutations or variants directly linked to APOA1A. However, alterations in the APOA1 gene can affect HDL cholesterol levels and, consequently, cardiovascular health.
There is ongoing research on the APOA1A protein and its role in lipid metabolism and cardiovascular health. Researchers are studying its interactions with other proteins and lipids, exploring its potential as a therapeutic target for cardiovascular diseases, and investigating its additional functions beyond lipid metabolism. Novel approaches, such as gene therapies and targeted drug development, are also being explored to modulate APOA1A levels and improve its functionality.
APOA1A protein, as a component of HDL particles, is involved in the process of reverse cholesterol transport. It helps remove excess cholesterol from arteries and peripheral tissues, preventing the accumulation of plaque. This process reduces the risk of cardiovascular diseases, such as atherosclerosis and coronary artery disease.
The APOA1A protein interacts with various other proteins and lipids to perform its functions. It associates with enzymes, receptor proteins, and other apolipoproteins to facilitate lipid metabolism and transport. It also interacts with phospholipids, cholesterol, and triglycerides, forming the core structure of HDL particles. These interactions are crucial for the formation and function of HDL particles in lipid metabolism.
Although APOA1A protein variations can affect HDL levels and cardiovascular health, it is not commonly used as a specific biomarker for cardiovascular diseases. Instead, other markers such as total cholesterol, LDL cholesterol, and HDL cholesterol levels are more commonly used to assess cardiovascular risk. However, APOA1A levels can be measured in research settings to understand HDL metabolism and its impact on cardiovascular health.
APOA1A levels are not commonly measured in clinical settings. Instead, total cholesterol, HDL cholesterol, and LDL cholesterol levels are typically measured as primary markers of cardiovascular risk. However, in research settings, APOA1A levels can be measured using laboratory techniques such as immunoassays or mass spectrometry.
Customer Reviews (4)
Write a reviewTheir expertise and prompt assistance have been instrumental in overcoming challenges and optimizing the use of the APOA1A protein in my studies.
Its purity and consistency have consistently generated trustworthy and reproducible results in my research.
the manufacturer's commitment to delivering excellent technical support has proven to be invaluable in troubleshooting any issues that arose during my experiments.
I am extremely satisfied with the high performance and the exceptional support associated with this protein, as it has greatly contributed to the success of my scientific endeavors.
Ask a Question for All APOA1A Products
Required fields are marked with *
My Review for All APOA1A Products
Required fields are marked with *
Inquiry Basket