Recombinant Zebrafish APOA1B
Cat.No. : | APOA1B-5882Z |
Product Overview : | Recombinant Zebrafish APOA1B full length or partial length protein was expressed. |
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Source : | Mammalian Cells |
Species : | Zebrafish |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | apoa1b apolipoprotein A-Ib [ Danio rerio (zebrafish) ] |
Official Symbol : | APOA1B |
Gene ID : | 100101640 |
mRNA Refseq : | NM_001100144 |
Protein Refseq : | NP_001093614 |
UniProt ID : | E7FES0 |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (16)
Ask a questionLike APOA1A, APOA1B is known to exhibit anti-inflammatory properties. HDL particles, which contain APOA1B, have been demonstrated to possess anti-inflammatory effects by reducing endothelial cell inflammation and modulating immune responses. However, more research is needed to understand the specific contributions of APOA1B in these anti-inflammatory processes.
Currently, there is limited knowledge about the specific effects of APOA1B mutations on lipid metabolism and the development of lipid disorders. Most studies have primarily focused on APOA1A mutations and their associations with disorders like familial hypoalphalipoproteinemia. Further research is needed to explore the impact of APOA1B mutations on lipid disorders.
Lifestyle factors, such as diet, exercise, and alcohol consumption, can influence APOA1B levels. A healthy lifestyle, including regular physical activity, consumption of a balanced diet with unsaturated fats, and moderate alcohol intake, has been associated with higher levels of APOA1B and beneficial lipid profiles.
Currently, there are no specific drugs or interventions known to target APOA1B specifically. Rather, therapies and interventions focus on modulating the overall lipid profile, including HDL cholesterol levels, which indirectly impact APOA1B functionality.
Research on the APOA1B protein is relatively limited compared to APOA1A. However, there is ongoing research in the field of lipoprotein metabolism, investigating the specific roles and functions of APOA1B and its potential implications in cardiovascular health and lipid disorders.
APOA1B levels can be influenced by age. Generally, there is a decline in APOA1B levels with increasing age, which is associated with changes in lipid metabolism and an increased risk of cardiovascular disease. However, individual variations and other factors can also impact APOA1B levels.
Research and studies have primarily focused on APOA1A due to its higher prevalence and clinical significance. As a result, there is limited information available regarding genetic disorders specifically associated with mutations in the APOA1B protein.
Limited research has been conducted specifically on genetic variations or polymorphisms of APOA1B. Most studies have primarily focused on APOA1A polymorphisms due to its higher prevalence and clinical relevance.
Currently, APOA1B levels are not commonly used as standalone biomarkers for cardiovascular risk assessment in clinical practice. Instead, other lipid markers, such as total cholesterol, HDL cholesterol, and LDL cholesterol, are typically assessed. However, ongoing research may shed light on the potential clinical utility of APOA1B as a biomarker or predictor of cardiovascular risk in the future.
APOA1B is primarily produced in the liver. Hepatocytes (liver cells) are the main site of APOA1B synthesis, as well as APOA1A synthesis. However, extra-hepatic tissues, such as the intestine, can also produce APOA1A and APOA1B in smaller quantities.
APOA1B levels are not commonly measured in clinical settings. Instead, total cholesterol, HDL cholesterol, and LDL cholesterol levels are typically assessed as primary lipid markers. However, in research settings, APOA1B levels can be measured using laboratory techniques such as immunoassays or mass spectrometry.
Limited research has explored potential associations between APOA1B and diseases or conditions. Most studies have primarily focused on APOA1A and its involvement in lipid metabolism and cardiovascular health.
The APOA1B protein is synthesized through a process called translation. The APOA1 gene, located on chromosome 11, is transcribed into mRNA (messenger RNA) in the cell nucleus. The mRNA then moves to the cytoplasm, where ribosomes read the genetic code and synthesize the APOA1B protein by linking together specific amino acids in the correct sequence.
There is ongoing research exploring therapeutic approaches targeting HDL metabolism, including APOA1, for the treatment of cardiovascular diseases. While specific interventions targeting APOA1B are not yet available, studies investigating the modulation of HDL functionality and subclasses may indirectly impact APOA1B and hold potential for future therapeutic strategies.
Yes, APOA1B is involved in cholesterol efflux, which is the process of removing cholesterol from cells. It interacts with cellular cholesterol transporters, such as ABCA1, promoting the transfer of cholesterol from peripheral tissues to HDL particles. This process is crucial for maintaining cholesterol homeostasis in the body.
Hormone levels may influence APOA1B levels to some extent, similar to APOA1A. However, specific research and data on the effects of hormones on APOA1B are scarce, and further studies are needed to fully understand this association.
Customer Reviews (4)
Write a reviewThe manufacturer's commitment to providing excellent technical support is truly commendable, as they have proven to be readily available to assist in resolving any concerns or challenges I encountered while working with the protein.
Their prompt and knowledgeable guidance has been instrumental in effectively addressing my queries and optimizing the utilization of the APOA1B protein in my studies.
The APOA1B protein is of exceptional quality, making it an ideal candidate to fulfill my experimental requirements.
Its purity and integrity have consistently delivered reliable and robust results in my research.
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