Recombinant Zebrafish AQP10B

• Cat.No.: AQP10B-5364Z
• Product Overview: Recombinant Zebrafish AQP10B full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: aqp10b aquaporin 10b [ Danio rerio (zebrafish) ]
• Official Symbol: AQP10B
• Gene ID: 100034395
• mRNA Refseq: NM_001083047
• Protein Refseq: NP_001076516
• UniProt ID: Q1L8T0

Reviews

04/17/2023

AQP10B protein has been successfully utilized in protein electron microscopy structure analysis.

07/21/2021

Its reliability in ELISA makes it a trusted tool for quantitative and qualitative protein analysis.

08/27/2019

With its superior binding affinity and specificity, AQP10B protein enables accurate and reliable detection of target analytes in various biological samples.

07/20/2017

Its stability and well-defined structure make it an excellent candidate for visualizing and studying the three-dimensional arrangement of proteins at a high resolution.

Q&As

Are there any known mutations or variations of the AQP10B gene?

Yes, mutations in the AQP10B gene have been associated with certain gastrointestinal disorders, such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).

What are the implications of studying the AQP10B protein?

Studying the AQP10B protein contributes to understanding the mechanisms of intestinal water transport, fluid homeostasis, and the pathophysiology of gastrointestinal disorders. It may lead to the discovery of new therapeutic approaches for such conditions.

Are there any known regulators or factors that affect the expression of AQP10B?

Several factors and signaling pathways can regulate the expression of AQP10B, including hormones like glucagon and insulin, as well as osmotic conditions and inflammatory cytokines.

Are there any known post-translational modifications of the AQP10B protein?

The post-translational modifications of the AQP10B protein have not been well-characterized thus far. Further research is needed to determine if any modifications, such as phosphorylation or glycosylation, occur and if they have functional implications.

How is the AQP10B protein regulated?

The expression and activity of the AQP10B protein can be regulated by various factors, including hormones, osmotic conditions, and inflammation.

Are there any known AQP10B protein interactions with other molecules or proteins?

The specific protein-protein interactions of AQP10B have not been extensively studied. However, as a member of the aquaporin family, it is likely to interact with other proteins or molecules involved in water transport or related physiological processes.

How is the expression of the AQP10B protein regulated?

The expression of the AQP10B protein can be regulated by various factors and signaling pathways. Hormones such as glucagon and insulin have been shown to influence its expression. Osmotic conditions, inflammatory cytokines, and certain transcription factors can also play a role in regulating its expression.

Can the AQP10B protein be used as a biomarker for gastrointestinal disorders?

Given its involvement in gastrointestinal disorders, the AQP10B protein has the potential to serve as a biomarker for certain conditions. However, more research is needed to validate its diagnostic and prognostic value in clinical settings.

Are there any known interactions or associations of the AQP10B protein with other proteins?

Further studies are needed to determine the specific protein-protein interactions or associations involving the AQP10B protein and its potential role in various cellular processes.

Is the AQP10B protein involved in any other physiological processes aside from the intestines?

While the AQP10B protein is primarily expressed in the intestines, it has been found to be present in low levels in other tissues such as the liver and adipose tissue. Its specific functions in these tissues are not yet fully understood and require further investigation.

Are there any drugs or compounds that specifically target the AQP10B protein?

At present, there are no known drugs or compounds that specifically target the AQP10B protein. However, with a better understanding of its structure and function, the development of targeted therapies may be possible in the future.

Has the crystal structure of the AQP10B protein been determined?

As of our current knowledge, the crystal structure of the AQP10B protein has not been resolved. Obtaining the crystal structure would provide valuable insights into its functional mechanisms and potential for therapeutic targeting.

Is there any potential for AQP10B protein modulation for therapeutic purposes?

The precise therapeutic potential of targeting the AQP10B protein is still under investigation. However, as it plays a role in intestinal water transport and certain gastrointestinal disorders, it poses a potential target for drug development in the future.

How is the AQP10B protein different from other aquaporins?

The AQP10B protein differs from other aquaporins in terms of its tissue distribution and the selectivity of its water transport. Its expression is mainly restricted to the intestines, distinguishing it from other aquaporins found in various tissues and organs.

Can the AQP10B protein be involved in disease development?

Yes, mutations in the AQP10B gene have been linked to gastrointestinal disorders such as IBS and IBD, indicating its potential role in the pathogenesis of these diseases. Further research is needed to understand the exact mechanisms.

Is the AQP10B protein found in any other tissues or organs?

Currently, the AQP10B protein has only been identified in the intestines, and its expression in other tissues or organs has not been reported.

Are there any known AQP10B protein mutations associated with specific clinical phenotypes?

Yes, specific mutations in the AQP10B gene have been linked to clinical phenotypes of gastrointestinal disorders, including altered stool consistency and increased intestinal permeability. These associations suggest an impact on disease manifestation and severity.

Can the AQP10B protein be targeted for therapeutic purposes?

The potential therapeutic targeting of AQP10B is still under investigation, but its role in intestinal water transport makes it a potential target for drug development in certain gastrointestinal disorders.

How is the AQP10B protein related to the AQP10A protein?

The AQP10B protein is a splice variant of the AQP10 gene, while the AQP10A protein is the full-length isoform. They share a high degree of sequence similarity and likely have similar functions, although their specific roles and regulations may differ.