RepSox, GMP Grade

• Cat.No.: RepSox-21
• Product Overview: RepSox (E-616452) (GMP) is a RepSox produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture.

Specification

• Description: RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor.
• Form: Solid, White to light yellow
• Target: TGF-β Receptor
• In Vitro: RepSox (GMP) (10 μM) induces MEFs differentiating to chemically induced pluripotent stem cells (CiPSCs). RepSox (GMP) (10 μM, in stage I-Stage III induction medium) induces hCiPS cells from HEFs. RepSox (GMP) together with Forskolin increases the number of proliferative cells in MEFs expressing MyoD, confirmed by increased EdU incorporation
• IC50 & Target: IC50: ALK5 autophosphorylation (4 nM)
• CAS: 446859-33-2
• Formula: C17H13N5
• Molecular Mass: 287.32
• Storage: 4 centigrade, sealed storage, away from moisture and light

Gene Information

• Pathway: TGF-beta/Smad
• Synonyms: RepSox; E-616452; SJN 2511