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The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
Synonyms
ACE2;angiotensin I converting enzyme 2;ACEH;angiotensin-converting enzyme 2;peptidyl-dipeptidase A;metalloprotease MPROT15;ACE-related carboxypeptidase;angiotensin-converting enzyme homolog;angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
ACE2 involved in several pathways and played different roles in them. We selected most pathways ACE2 participated on our site, such as Renin-angiotensin system,Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
ACE2 has several biochemical functions, for example, carboxypeptidase activity,endopeptidase activity,glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACE2 itself. We selected most functions ACE2 had, and list some proteins which have the same functions with ACE2. You can find most of the proteins on our site.
ACE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACE2.
Sui, JH; Deming, M; et al. Effects of Human Anti-Spike Protein Receptor Binding Domain Antibodies on Severe Acute Respiratory Syndrome Coronavirus Neutralization Escape and Fitness. JOURNAL OF VIROLOGY 88:13769-13780(2014).
Prasad, T; Verma, A; et al. Expression and cellular localization of the Mas receptor in the adult and developing mouse retina. MOLECULAR VISION 20:1443-1455(2014).
