ace2
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  • Official Full Name
  • angiotensin I converting enzyme 2
  • Background
  • The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ACE2; angiotensin I converting enzyme 2; ACEH; angiotensin-converting enzyme 2; peptidyl-dipeptidase A; metalloprotease MPROT15; ACE-related carboxypeptidase; angiotensin-converting enzyme homolog; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2;
Cat.#:ACE2-221HTag:
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human ACE2 protein, Fc-tagged
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Cat.#:ACE2-229HTag:His/Avi
Source (Host):Mammalian cellsSpecies:Human
Product nameRecombinant Human ACE2 protein, His/Avi-tagged
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Cat.#:ACE2-185HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACE2 Protein, Fc-tagged
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Cat.#:ACE2-67HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACE2, FLAG-tagged
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Cat.#:ACE2-68HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACE2, Fc-tagged
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Cat.#:ACE2-736HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACE2, His-tagged
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Cat.#:ACE2-745HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human ACE2, His-tagged
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Cat.#:Ace2-1183MTag:Fc|His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ace2, Fc-His tagged
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Cat.#:Ace2-1184MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ace2, His tagged
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Cat.#:Ace2-1930MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ace2 protein, His & T7-tagged
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Cat.#:ACE2-69MTag:Flag
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ACE2, FLAG-tagged
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Cat.#:Ace2-761MTag:His
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Ace2 Protein, His-tagged
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Cat.#:Ace2-1194RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Ace2, His tagged
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Cat.#:Ace2-1931RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ace2 protein, His & T7-tagged
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Cat.#:Ace2-639RTag:His
Source (Host):NSO cellsSpecies:Rat
Product nameRecombinant Rat Ace2, His-tagged
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Cat.#:ACE2-107CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACE2, Fc tagged
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Cat.#:ACE2-108CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACE2, His tagged
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Cat.#:ACE2-206RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ACE2 Protein, His-tagged
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Cat.#:ACE2-1691ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ACE2
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Cat.#:ACE2-3100HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACE2 cell lysate
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Cat.#:ACE2-2085MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ACE2 cell lysate
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Cat.#:ACE2-1851RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat ACE2 cell lysate
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Cat.#:ACE2-887CCLTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACE2 cell lysate
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Cat.#:Kit-2101Tag:N/A
Source (Host):Species:
Product nameAngiotensin II Converting Enzyme Inhibitor Screening Kit
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Cat.#:Kit-2210Tag:N/A
Source (Host):Species:
Product nameAngiotensin II Converting Enzyme (ACE2) Activity Assay Kit (Fluorometric)
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Involved Pathway

ACE2 involved in several pathways and played different roles in them. We selected most pathways ACE2 participated on our site, such as Renin-angiotensin system, Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Renin-angiotensin system
KLK1B24; KLK1B8; KLK1B5; ACE; REN2; MME; PREP; NLN; ACE2; MRGPRD
Protein digestion and absorption
COL7A1; COL21A1; PRSS3; SLC9A3; SLC15A1; MEP1A; ACE2; SLC38A2; COL13A1; COL6A5

Protein Function

ACE2 has several biochemical functions, for example, carboxypeptidase activity, endopeptidase activity, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACE2 itself. We selected most functions ACE2 had, and list some proteins which have the same functions with ACE2. You can find most of the proteins on our site.
Function
Related Protein
Function carboxypeptidase activity
Related Protein CPM; CPB1; AEBP1; BLMH; AGBL4; CPE; CNDP2; ACE2; NAALAD2; NAALADL1
Function endopeptidase activity
Related Protein MMP12; CPS1; PSMB1; HTRA4; PSMA5; ADAM10; RHBDD1; PSMB8; PSEN2; MMP1A
Function glycoprotein binding
Related Protein SELP; APOH; Serpina1b; SERPINA1; PTBP3; CSNK1D; LCK; THBS1; Itgam&Itgb2; ERLEC1
Function NOT metallopeptidase activity
Related Protein ACE2
Function NOT peptidyl-dipeptidase activity
Related Protein ACE2
Function protein binding
Related Protein DAP3; MINOS1; DNTTIP1; SUN1; Trf; FAM167A; SERTAD1; TMEM119; GYS1; ID3
Function virus receptor activity
Related Protein SLC10A1; CD209A; TYRO3; EFNB2; CD86; HSPA1B; CLEC4G; NCAM1; IDE; CD46
Function zinc ion binding
Related Protein TRIM35-27; LMX1A; LIMK1; LNPEP; ZDHHC20; RABGEF1L; FBXO40.1; RBM5; RP9; MKRN3

Interacting Protein

ACE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACE2.
CALM1

ACE2 Related Articles

Sui, JH; Deming, M; et al. Effects of Human Anti-Spike Protein Receptor Binding Domain Antibodies on Severe Acute Respiratory Syndrome Coronavirus Neutralization Escape and Fitness. JOURNAL OF VIROLOGY 88:13769-13780(2014).
Prasad, T; Verma, A; et al. Expression and cellular localization of the Mas receptor in the adult and developing mouse retina. MOLECULAR VISION 20:1443-1455(2014).